New York University Langone Health System New York NY USA.
Cardiology Division Emory University School of Medicine Atlanta GA USA.
J Am Heart Assoc. 2023 Sep 19;12(18):e029971. doi: 10.1161/JAHA.123.029971.
Acute myocardial infarction is an important cause of death worldwide. While it often affects patients of older age, acute myocardial infarction is garnering more attention as a significant cause of morbidity and mortality among young patients (<45 years of age). More specifically, there is a focus on recognizing the unique etiologies for myocardial infarction in these younger patients as nonatherosclerotic etiologies occur more frequently in this population. As such, there is a potential for delayed and inaccurate diagnoses and treatments that can carry serious clinical implications. The understanding of acute myocardial infarction manifestations in young patients is evolving, but there remains a significant need for better strategies to rapidly diagnose, risk stratify, and manage such patients. This comprehensive review explores the various etiologies for acute myocardial infarction in young adults and outlines the approach to efficient diagnosis and management for these unique patient phenotypes.
急性心肌梗死是全球范围内重要的死亡原因。尽管它通常影响老年患者,但急性心肌梗死作为年轻患者(<45 岁)发病率和死亡率的重要原因,越来越受到关注。更具体地说,人们越来越关注认识到这些年轻患者心肌梗死的独特病因,因为非动脉粥样硬化性病因在该人群中更为常见。因此,存在诊断和治疗延迟以及不准确的潜在风险,这可能会带来严重的临床影响。年轻人急性心肌梗死表现的认识在不断发展,但仍需要更好的策略来快速诊断、风险分层和管理此类患者。本综述探讨了年轻人急性心肌梗死的各种病因,并概述了针对这些独特患者表型的有效诊断和管理方法。