From the Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
Department of Neurosurgery, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
Pediatr Infect Dis J. 2023 Dec 1;42(12):1121-1123. doi: 10.1097/INF.0000000000004116. Epub 2023 Sep 13.
This case describes a neonate who presented with spontaneous Clostridium perfringens meningitis and brain abscess. The abscess was drained, and the infant completed a 6-week course of antibiotics. Throughout this time the infant remained well with no need for intensive care. C. perfringens central nervous system infections are associated with trauma and poor outcomes. This case highlights that the spectrum of disease can include spontaneous infection with a relatively mildly clinical course demonstrating the importance of 16s polymerase chain reaction in culture-negative cases and its role in detecting rare causes of central nervous system infections such as C. perfringens .
本病例描述了一例新生儿自发性梭状芽孢杆菌性脑膜炎和脑脓肿。脓肿被引流，婴儿完成了 6 周的抗生素疗程。在此期间，婴儿情况良好，无需重症监护。梭状芽孢杆菌属中枢神经系统感染与创伤和不良预后有关。本病例表明，疾病谱可包括自发性感染，临床过程相对较轻，这突显了 16s 聚合酶链反应在培养阴性病例中的重要性，以及其在检测罕见中枢神经系统感染病因（如梭状芽孢杆菌）中的作用。
