Academic Urology Unit, The University of Sheffield, Sheffield, UK.
Department of Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
J Clin Pathol. 2023 Dec;76(12):793-797. doi: 10.1136/jcp-2023-209017. Epub 2023 Sep 19.
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations in are linked to breast and bladder cancer. GATA3 expression is a feature of the luminal subtype of bladder cancer and has implications for immune status and therapeutic response. It also has clinical relevance in squamous cell carcinomas and soft tissue sarcomas. This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical marker.
GATA 结合蛋白 3（GATA3）是一种锌指先锋转录因子，参与多种过程。GATA3 通过结合核小体 DNA 并促进染色质重塑来调节基因表达。翻译后修饰调节其活性。在发育过程中，GATA3 在细胞分化中发挥关键作用。突变与乳腺癌和膀胱癌有关。GATA3 的表达是膀胱癌腔型亚型的一个特征，对免疫状态和治疗反应有影响。它在鳞状细胞癌和软组织肉瘤中也具有临床意义。本文综述了 GATA3 的结构和功能、在癌症中的作用以及作为免疫组织化学标志物的应用和陷阱。
