预测射血分数保留的心力衰竭（HFpEF）和心肌纤维化患者的治疗反应。借助心脏磁共振成像（CMR）识别有用的工具。 - Suppr

Predicting treatment response in patients with HFpEF and myocardial fibrosis. Identifying useful tools with the help of CMR.

作者信息

Stoiber Lukas, Kasiakogias Alexandros

机构信息

Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Guy's and St. Thomas' NHS Foundation Trust, Sydney St, SW3 6NP, London, United Kingdom.

出版信息

Int J Cardiovasc Imaging. 2022 Oct;38(10):2209-2211. doi: 10.1007/s10554-022-02605-z. Epub 2022 Aug 6.

DOI:10.1007/s10554-022-02605-z

PMID:37726471

Abstract

摘要

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Predicting treatment response in patients with HFpEF and myocardial fibrosis. Identifying useful tools with the help of CMR.预测射血分数保留的心力衰竭（HFpEF）和心肌纤维化患者的治疗反应。借助心脏磁共振成像（CMR）识别有用的工具。

Int J Cardiovasc Imaging. 2022 Oct;38(10):2209-2211. doi: 10.1007/s10554-022-02605-z. Epub 2022 Aug 6.

Relationship between diffuse fibrosis assessed by CMR and depressed myocardial strain in different stages of heart failure.CMR 评估的弥漫性纤维化与心力衰竭不同阶段的心肌应变降低之间的关系。

Eur J Radiol. 2023 Jul;164:110848. doi: 10.1016/j.ejrad.2023.110848. Epub 2023 Apr 26.

Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction: Association With Baseline Disease Severity and Subsequent Outcome.心肌纤维化与射血分数保留的心力衰竭的时间关系：与基线疾病严重程度和随后的结局的关联。

JAMA Cardiol. 2017 Sep 1;2(9):995-1006. doi: 10.1001/jamacardio.2017.2511.

Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.磁共振评估局灶性和弥漫性纤维化与射血分数保留心力衰竭临床结局的关系。

JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 2):2291-2301. doi: 10.1016/j.jcmg.2018.11.031. Epub 2019 Feb 13.

Clinical evaluation of infiltrative cardiomyopathies resulting in heart failure with preserved ejection fraction.射血分数保留的心力衰竭所致浸润性心肌病的临床评估

Rev Cardiovasc Med. 2020 Jun 30;21(2):181-190. doi: 10.31083/j.rcm.2020.02.65.

Magnetic Resonance Imaging of Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction: Ready for Prime Time?射血分数保留的心力衰竭中心肌纤维化的磁共振成像：准备好进入黄金时代了吗？

JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 2):2302-2304. doi: 10.1016/j.jcmg.2018.12.019. Epub 2019 Feb 13.

RT-CMR Imaging for Noninvasive Characterization of HFpEF: Medium-Term Outcomes of the HFpEF Stress Trial.用于射血分数保留的心力衰竭（HFpEF）无创特征分析的实时心脏磁共振成像（RT-CMR）：HFpEF应激试验的中期结果

JACC Cardiovasc Imaging. 2022 May;15(5):943-945. doi: 10.1016/j.jcmg.2021.11.013. Epub 2022 Jan 12.

Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction: A Modifiable Therapeutic Target?射血分数保留的心力衰竭中的微血管功能障碍：一个可改变的治疗靶点？

JACC Cardiovasc Imaging. 2022 Jun;15(6):1012-1014. doi: 10.1016/j.jcmg.2022.04.008.

Global Longitudinal Strain by CMR Feature Tracking Is Associated With Outcome in HFPEF.通过心脏磁共振特征追踪测量的整体纵向应变与射血分数保留的心力衰竭的预后相关。

JACC Cardiovasc Imaging. 2019 Aug;12(8 Pt 1):1585-1587. doi: 10.1016/j.jcmg.2019.02.016. Epub 2019 Apr 17.

Diagnostic and Prognostic Value of CMR T-Mapping in Patients With Heart Failure and Preserved Ejection Fraction.心脏磁共振T值映射在射血分数保留的心力衰竭患者中的诊断和预后价值

Rev Esp Cardiol (Engl Ed). 2017 Oct;70(10):848-855. doi: 10.1016/j.rec.2017.02.018. Epub 2017 Mar 15.

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Advancing Cardiovascular Diagnostics: The Expanding Role of CMR in Heart Failure and Cardiomyopathies.推进心血管诊断：心脏磁共振成像在心力衰竭和心肌病中不断扩大的作用

J Clin Med. 2025 Jan 28;14(3):865. doi: 10.3390/jcm14030865.

本文引用的文献

Predictors of myocardial fibrosis and response to anti-fibrotic therapy in heart failure with preserved ejection fraction.射血分数保留的心力衰竭中心肌纤维化的预测因素及抗纤维化治疗反应

Int J Cardiovasc Imaging. 2022 Jul;38(7):1569-1578. doi: 10.1007/s10554-022-02544-9. Epub 2022 Feb 9.

Empagliflozin in Heart Failure with a Preserved Ejection Fraction.恩格列净治疗射血分数保留的心力衰竭。

N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27.

Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial.吡非尼酮治疗射血分数保留的心力衰竭：一项随机 2 期试验。

Nat Med. 2021 Aug;27(8):1477-1482. doi: 10.1038/s41591-021-01452-0. Epub 2021 Aug 12.

Hypertension and heart failure with preserved ejection fraction: position paper by the European Society of Hypertension.高血压合并射血分数保留的心力衰竭：欧洲高血压学会立场文件。

J Hypertens. 2021 Aug 1;39(8):1522-1545. doi: 10.1097/HJH.0000000000002910.

The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial.螺内酯对心力衰竭高危人群心血管功能和纤维化标志物的影响：衰老中心血管 'OMICS' 研究（HOMAGE）随机临床试验。

Eur Heart J. 2021 Feb 11;42(6):684-696. doi: 10.1093/eurheartj/ehaa758.

Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future.射血分数保留的心力衰竭的治疗方法：过去、现在和未来。

Clin Res Cardiol. 2020 Sep;109(9):1079-1098. doi: 10.1007/s00392-020-01633-w. Epub 2020 Mar 31.

Covariate adjusted reanalysis of the I-Preserve trial.I-Preserve试验的协变量调整再分析

Clin Res Cardiol. 2020 Nov;109(11):1358-1365. doi: 10.1007/s00392-020-01632-x. Epub 2020 Mar 25.

Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary.射血分数保留的心力衰竭研究重点：美国国立心肺血液研究所工作组总结。

Circulation. 2020 Mar 24;141(12):1001-1026. doi: 10.1161/CIRCULATIONAHA.119.041886. Epub 2020 Mar 23.

Interdependence of Atrial Fibrillation and Heart Failure With a Preserved Ejection Fraction Reflects a Common Underlying Atrial and Ventricular Myopathy.心房颤动与射血分数保留的心力衰竭之间的相互依存关系反映了一种共同的潜在心房和心室肌病。

Circulation. 2020 Jan 7;141(1):4-6. doi: 10.1161/CIRCULATIONAHA.119.042996. Epub 2019 Dec 30.

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.血管紧张素-脑啡肽酶抑制剂在射血分数保留的心力衰竭中的应用。

N Engl J Med. 2019 Oct 24;381(17):1609-1620. doi: 10.1056/NEJMoa1908655. Epub 2019 Sep 1.

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Predicting treatment response in patients with HFpEF and myocardial fibrosis. Identifying useful tools with the help of CMR.

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