Department of Neuromedicine and Movement Science, NTNU, Faculty of Medicine, Norwegian University of Science and Technology, Post Box 8905, N-7491, Trondheim, Norway.
Department of Circulation and Medical Imaging, NTNU, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
BMC Musculoskelet Disord. 2023 Sep 19;24(1):743. doi: 10.1186/s12891-023-06871-3.
In psoriatic arthritis (PsA) there is a theoretical risk of increased disease activity related to strenuous physical activity, including exercise. We evaluated the effect of high intensity interval training (HIIT) on objective measures of inflammation in PsA assessed by ultrasound (US) of peripheral joints and entheses, and by bone marrow edema (BME) on MRI of the sacroiliac joints (SIJ) and spine.
We randomly assigned 67 PsA patients to an intervention group that performed structured HIIT for 11 weeks, or to a control group instructed not to change their physical exercise habits. Outcome measures included US evaluation of the total cohort and MRI in a subgroup of 41; both assessed at 3 months. We calculated the proportions with an increased US B-mode and power-doppler (PD) signal of joints and entheses and Spondyloarthritis-Research-Consortium-of-Canada (SPARCC)-BME score of the SIJ and spine for both groups.
Proportions with an increased US B-mode score of the joints were 32% and 28% in HIIT and control groups, respectively. Corresponding proportions of PD scores of the joints were 7% and 10% and PD scores of entheses were 32% and 31%. The proportions with increased MRI BME of the SIJ were 6% in the HIIT group and 10% in the control group. Corresponding proportions were 6% and 5% for the MRI BME of the spine.
In PsA patients with a low to moderate disease activity, there was no clear evidence of objectively measured increased inflammation after HIIT, as evaluated by US and MRI.
ClinicalTrials.gov NCT02995460 (16/12/2016).
在银屑病关节炎（PsA）中，剧烈的体力活动（包括运动）与疾病活动增加相关，这是一种理论风险。我们评估了高强度间歇训练（HIIT）对通过外周关节和附着点的超声（US）以及骶髂关节（SIJ）和脊柱的骨髓水肿（BME）的 MRI 评估的 PsA 的炎症的客观指标的影响。
我们将 67 例 PsA 患者随机分为干预组，该组进行了 11 周的结构化 HIIT，或对照组，指导他们不要改变其体育锻炼习惯。主要结局指标包括总队列的 US 评估和 41 例亚组的 MRI；两组均在 3 个月时进行评估。我们计算了两组中关节和附着点的 US B 型和功率多普勒（PD）信号以及 SIJ 和脊柱的 SPARCC-BME 评分增加的患者比例。
HIIT 组和对照组的关节 US B 型评分增加的比例分别为 32%和 28%。关节 PD 评分增加的比例分别为 7%和 10%，附着点 PD 评分增加的比例分别为 32%和 31%。HIIT 组的 SIJ MRI BME 增加的比例为 6%，对照组为 10%。脊柱 MRI BME 增加的比例分别为 6%和 5%。
在疾病活动度低至中度的 PsA 患者中，HIIT 后通过 US 和 MRI 评估并未发现明显的炎症增加的客观证据。
ClinicalTrials.gov NCT02995460（2016 年 12 月 16 日）。
