Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Eur J Med Res. 2023 Sep 19;28(1):355. doi: 10.1186/s40001-023-01188-2.
The triglyceride and glucose index (TyG), as a surrogate of insulin resistance (IR), is closely associated with non-alcoholic fatty liver disease (NAFLD). However, the association between the TyG index and NAFLD in atrial fibrillation (AF) is unknown. Therefore, the purpose of this study is to explore the association between the TyG index and NAFLD in AF.
This retrospective study was performed at Nanchang University's Second Affiliated Hospital. The AF patients who were hospitalized from January 2021 to December 2022 were enrolled. The association between the TyG index and NAFLD in AF patients was assessed by logistic regression and restricted cubic spline analysis. The ability of TyG index for identifying NAFLD was estimated by the area under the receiver operating characteristic (ROC).
In this study, 632 people participated in the final analysis, with 176 (27.84%) having NAFLD. In the full adjustment model, there is an association between the TyG index and NAFLD [per 1 unit increment; odds ratios (ORs): 3.28; 95% confidence interval (CI) 2.14, 5.03]. Compared to the lowest tertile (TyG index < 8.29), the ORs for the highest tertile (TyG index ≥ 8.82) were 4.15 (95%CI: 2.28, 7.53). Dose-response analysis showed that the TyG index and NAFLD have a nearly linear relationship (P non-linear = 0.71). The area under the curve (AUC) of the TyG index is 0.735.
Our findings showed a significant association between the TyG index and NAFLD. The TyG index may be a good marker for predicting NAFLD in AF patients.
甘油三酯-葡萄糖指数（TyG）作为胰岛素抵抗（IR）的替代指标，与非酒精性脂肪性肝病（NAFLD）密切相关。然而，TyG 指数与心房颤动（AF）中 NAFLD 的关系尚不清楚。因此，本研究旨在探讨 AF 患者中 TyG 指数与 NAFLD 的关系。
本回顾性研究在南昌大学第二附属医院进行。纳入 2021 年 1 月至 2022 年 12 月住院的 AF 患者。采用 logistic 回归和限制立方样条分析评估 TyG 指数与 AF 患者 NAFLD 的关系。采用受试者工作特征（ROC）曲线下面积（AUC）评估 TyG 指数识别 NAFLD 的能力。
本研究共纳入 632 人，最终分析 176 人（27.84%）患有 NAFLD。在全调整模型中，TyG 指数与 NAFLD 相关[每增加 1 单位；比值比（ORs）：3.28；95%置信区间（CI）：2.14，5.03]。与最低三分位组（TyG 指数<8.29）相比，最高三分位组（TyG 指数≥8.82）的 OR 为 4.15（95%CI：2.28，7.53）。剂量反应分析显示，TyG 指数与 NAFLD 呈近似线性关系（P 非线性=0.71）。TyG 指数的 AUC 为 0.735。
本研究结果表明，TyG 指数与 NAFLD 显著相关。TyG 指数可能是预测 AF 患者 NAFLD 的一个较好指标。
