Dar Saleha, Koirala Sabina, Khan Arooba, Bellary Mounika Deepthi, Patel Arya V, Mathew Bejoi, Singh Rahul, Baigam Nahida, Razzaq Waleed, Abdin Zain U, Khawaja Uzzam Ahmed
Department of Adult Medicine, Louisiana State University Health Sciences Center, Shreveport, USA.
Department of Medicine, Gandaki Medical College, Pokhara, NPL.
Cureus. 2023 Aug 18;15(8):e43725. doi: 10.7759/cureus.43725. eCollection 2023 Aug.
This review aimed to evaluate the mechanism of premature cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) patients, particularly in the female population, and emphasize the need for early management interventions; explore the association between SLE and two autoimmune diseases, myasthenia gravis (MG) and antiphospholipid antibody syndrome (APS), and their management strategies; and evaluate the effectiveness of pharmacological and non-pharmacological interventions in managing SLE, focusing on premenopausal females, females of childbearing age, and pregnant patients. We conducted a comprehensive literature review to achieve these objectives using various databases, including PubMed, Google Scholar, and Cochrane. The collected data were analyzed and synthesized to provide an evidence-based overview of SLE, its management strategies as an independent disease, and some disease associations. The treatment should be focused on remission, preventing organ damage, and improving the overall quality of life (QOL). Extensive emphasis should also be focused on diagnosing SLE and concurrent underlying secondary diseases timely and managing them appropriately.
本综述旨在评估系统性红斑狼疮（SLE）患者，尤其是女性群体中过早发生心血管疾病（CVD）的机制，并强调早期管理干预的必要性；探讨SLE与另外两种自身免疫性疾病——重症肌无力（MG）和抗磷脂抗体综合征（APS）之间的关联及其管理策略；评估药物和非药物干预措施在SLE管理中的有效性，重点关注绝经前女性、育龄女性和孕妇。为实现这些目标，我们使用了包括PubMed、谷歌学术和考克兰在内的各种数据库进行了全面的文献综述。对收集到的数据进行了分析和综合，以提供关于SLE、其作为一种独立疾病的管理策略以及一些疾病关联的循证概述。治疗应侧重于缓解病情、预防器官损伤以及提高整体生活质量（QOL）。还应广泛强调及时诊断SLE和并发的潜在继发性疾病并进行适当管理。
