Department of Pharmacy Practice, University of Findlay College of Pharmacy, OH, USA.
Department of Pharmacy, Mercy Health St Anne Hospital, Toledo, OH, USA.
Perit Dial Int. 2023 Nov;43(6):431-441. doi: 10.1177/08968608231196034. Epub 2023 Sep 20.
To optimise antimicrobial administration in patients with peritoneal dialysis (PD)-related peritonitis, healthcare providers need literature-based information to develop patient-centred pharmacotherapeutic plans. Traditional PD solutions promote osmosis using dextrose or icodextrin with a lactate buffer. Newer PD solutions have modified the osmotic vehicle and buffer. Knowledge of antimicrobial compatibility and stability with newer PD solutions will assist with determining the route of antimicrobial administration as compatible and stable solutions could be delivered directly to the peritoneum using intraperitoneal administration. This review updates the compatibility and stability of antimicrobial additives in newer PD solutions for PD-related peritonitis.
为了优化腹膜透析（PD）相关性腹膜炎患者的抗菌药物管理，医疗保健提供者需要基于文献的信息来制定以患者为中心的药物治疗计划。传统的 PD 溶液使用葡萄糖或艾考糊精加乳酸缓冲液促进渗透。新型 PD 溶液改变了渗透载体和缓冲液。了解与新型 PD 溶液的抗菌药物相容性和稳定性有助于确定抗菌药物给药途径，因为相容且稳定的溶液可以通过腹腔内给药直接输送到腹膜。本文综述了 PD 相关性腹膜炎中新型 PD 溶液中抗菌药物添加剂的相容性和稳定性。
