Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco.
Ibn Sina University Hospital Center, Rabat, Morocco.
J Oncol Pharm Pract. 2024 Oct;30(7):1152-1159. doi: 10.1177/10781552231203403. Epub 2023 Sep 20.
Most intravenous anticancer drugs are administered in a dose per unit area or body weight, if not promptly administered to another patient cytotoxic leftover would be destroyed. To contain wastage, low-cost measures are highly desirable to contain and reduce expenditures without impairing the quality of care. The objective of the study is to evaluate the cost saved through the use of the two cytotoxic waste management techniques implemented in National Institute of Oncology's centralized chemotherapy preparation unit, vial sharing and dose rounding.
A 6-month prospective single centre study from 1 February to 1 August 2023 at the National Institute of Oncology of Rabat in Morocco. The number of prepared preparations and amount of drug saved by both vial sharing and dose rounding was collected using the centralized chemotherapy preparation unit's 'leftover tracking file', the corresponding cost saved were calculated and then compared for each technique and with 2018 results.
In total, 18,218 preparations were considered in the 6-month study. With the vial sharing technique 636,524.5 mg were saved corresponding to 246,031.4 (USD) saved cost, against 212,838.4 mg by dose rounding corresponding to 75,598.5 (USD) saved cost. This saving corresponded to a total of 321,629.4 (USD). Compared to the 2018 results leftovers costs saved by vial sharing corresponded to 289,972.05 (USD) by vial sharing technique for 1-year extrapolated period, and this study shows a saved cost of 321,629.9 (USD) by both vial sharing and dose rounding techniques.
Dose rounding technique combined with vial sharing allowed National Institute of Oncology's centralized chemotherapy preparation unit to limit expensive cytotoxic cost wastage, highlighting these technique benefits.
大多数静脉内抗癌药物是按照单位面积或体重剂量给药的，如果不及时给予另一位患者，细胞毒性残留药物将被破坏。为了控制浪费，非常需要采取低成本措施来控制和减少支出，同时不影响护理质量。本研究的目的是评估在摩洛哥拉巴特国家肿瘤研究所的集中化疗准备单位实施的两种细胞毒性废物管理技术（瓶共享和剂量舍入）所节省的成本。
这是一项从 2023 年 2 月 1 日至 8 月 1 日在摩洛哥拉巴特国家肿瘤研究所进行的为期 6 个月的前瞻性单中心研究。通过集中化疗准备单位的“剩余跟踪文件”收集两种瓶共享和剂量舍入方法节省的准备制剂数量和药物数量，计算相应的节省成本，然后对每种技术进行比较，并与 2018 年的结果进行比较。
在 6 个月的研究中，共考虑了 18218 种制剂。通过瓶共享技术可节省 636524.5 毫克，相当于节省 246031.4 美元（USD）的成本，而剂量舍入法可节省 212838.4 毫克，相当于节省 75598.5 美元（USD）的成本。这一节省相当于总共节省了 321629.4 美元（USD）。与 2018 年的结果相比，瓶共享技术通过瓶共享技术可节省 289972.05 美元（USD）的剩余成本，在 1 年的外推期内，本研究显示通过瓶共享和剂量舍入技术总共可节省 321629.9 美元（USD）的成本。
剂量舍入技术与瓶共享技术相结合，使国家肿瘤研究所的集中化疗准备单位能够限制昂贵的细胞毒性药物浪费，突出了这些技术的优势。
