青春期少女的月经紊乱是否与代谢紊乱有关？

Are menstrual disorders in adolescent girls related to metabolic disorders?

机构信息

Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia in Katowice, Poland.

Student Scientific Association, Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, School of Medicine in Katowice, Poland.

出版信息

Pediatr Endocrinol Diabetes Metab. 2023;29(2):75-82. doi: 10.5114/pedm.2023.125364.

DOI:10.5114/pedm.2023.125364

PMID:37728458

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10411084/

Abstract

INTRODUCTION

Menstrual disorders in adolescent girls are a common clinical problem. They are often accompanied by lipid and glucose metabolism disturbances. The aim of the study was to investigate to what extent the metabolic profile of adolescent girls relates to the severity of their menstrual disorders.

MATERIAL AND METHODS

The study included 165 girls with menstrual disturbances and 49 regularly menstruating girls (REG) without clinical hyperandrogenism, matched for age and BMI. The subjects from the study group were divided into 2 subgroups: OLIGO - 111 girls with oligomenorrhea and SA - 54 girls with secondary amenorrhoea. In all girls, hormonal, lipid, and carbohydrate metabolism profiles were assessed.

RESULTS

In the SA subgroup concentrations of total cholesterol (TC) and LDL were significantly higher than in the REG and OLIGO groups. Triglyceride (TG) concentration was also the highest in the SA group and significantly higher than in the REG group. The prevalence of lipid metabolism disorders was higher in the SA group (65%) vs. the REG (40%) and OLIGO (51%) groups. The subgroups did not differ significantly in terms of fasting and OGTT glucose and insulin as well as HOMA-IR. TyG index was significantly higher in the OLIGO and SA groups than in the REG group. BMI z-score correlated with TG, LDL, fasting and 120' OGTT glucose and insulin, HOMA-IR, and TyG and negatively with HDL. No relationship between hormonal concentration and metabolic disturbances was found.

CONCLUSIONS

Adolescent girls with menstrual disorders are insulin resistant, regardless of PCOS diagnosis. The severity of menstrual disorders may be related to the incidence of lipid disorders in adolescent girls.

摘要

简介

青春期少女的月经紊乱是一种常见的临床问题。它们常伴有脂质和糖代谢紊乱。本研究旨在探讨青春期少女的代谢特征与月经紊乱严重程度的关系。

材料与方法

本研究纳入了 165 名月经紊乱的少女和 49 名月经正常且无临床高雄激素血症的少女（REG），按年龄和 BMI 匹配。研究组的受试者分为 2 个亚组：OLIGO-111 名月经稀发的少女和 SA-54 名继发性闭经的少女。所有少女均评估了激素、脂质和碳水化合物代谢特征。

结果

SA 亚组的总胆固醇（TC）和 LDL 浓度明显高于 REG 和 OLIGO 组。甘油三酯（TG）浓度也在 SA 组最高，明显高于 REG 组。脂质代谢紊乱在 SA 组（65%）较 REG（40%）和 OLIGO（51%）组更为常见。SA 组和 OLIGO 组的空腹和 OGTT 血糖和胰岛素以及 HOMA-IR 无显著差异。OLIGO 组和 SA 组的 TyG 指数明显高于 REG 组。BMI z 评分与 TG、LDL、空腹和 120'OGTT 血糖和胰岛素、HOMA-IR、TyG 呈正相关，与 HDL 呈负相关。未发现激素浓度与代谢紊乱之间存在相关性。