Joshi U M, Thornburg J E
J Toxicol Environ Health. 1986;19(3):337-44. doi: 10.1080/15287398609530932.
The purpose of this study was to determine whether cimetidine exerts a protective effect against toxicity of organophosphate pesticides requiring metabolic activation in mice and rats. In both species, pretreatment with cimetidine (75 mg/kg/ip) 30 min prior to methylparathion (MP) reduced lethality and delayed the onset of cholinergic signs of toxicity. In contrast when cimetidine was administered simultaneously with MP to mice, neither MP-induced lethality nor cholinergic signs of toxicity were altered. Moreover, cimetidine pretreatment failed to decrease parathion-induced toxicity in mice. In conclusion, pretreatment with cimetidine decreases the toxicity of MP but not of parathion in mice and rats.
本研究的目的是确定西咪替丁是否对需要代谢活化的有机磷酸酯类农药在小鼠和大鼠中的毒性具有保护作用。在这两个物种中，在甲基对硫磷（MP）给药前30分钟腹腔注射西咪替丁（75mg/kg）可降低致死率，并延迟毒性胆碱能体征的出现。相反，当西咪替丁与MP同时给予小鼠时，MP诱导的致死率和毒性胆碱能体征均未改变。此外，西咪替丁预处理未能降低对硫磷对小鼠的毒性。总之，西咪替丁预处理可降低MP对小鼠和大鼠的毒性，但不能降低对硫磷的毒性。
