Governa M, Valentino M, Tosi P, Luzi P, Miracco C, Sartorelli E, Loi F, Franzinelli A, Gori R
J Toxicol Environ Health. 1986;19(3):403-12. doi: 10.1080/15287398609530938.
Wistar rats were injected intratracheally with pyrite particles and after 6 and 12 mo, lungs were evaluated for histological changes. Results were compared with rats that were given particles of galena, lead silicate, travertine, and quartz. Under the light microscope no significant changes were observed in the lungs from animals treated with galena, lead silicate, and travertine. In the lungs from animals that received quartz, a typical nodular fibrosis was observed. Moreover, both pyrite-treated rats and quartz-treated rats developed pulmonary alveolar lipoproteinosis; the lesions were much less prominent and severe in animals injected with pyrite than with quartz. These results indicate that pyrite, like only a few other types of dust that are different from quartz, can evoke the development of pulmonary alveolar lipoproteinosis in rats.
将黄铁矿颗粒经气管内注入Wistar大鼠体内，6个月和12个月后，评估肺部的组织学变化。将结果与给予方铅矿、硅酸铅、钙华和石英颗粒的大鼠进行比较。在光学显微镜下，接受方铅矿、硅酸铅和钙华处理的动物肺部未观察到明显变化。在接受石英处理的动物肺部，观察到典型的结节性纤维化。此外，黄铁矿处理的大鼠和石英处理的大鼠均发生肺泡蛋白沉积症；与石英处理的动物相比，注射黄铁矿的动物病变不那么突出和严重。这些结果表明，黄铁矿与其他少数几种不同于石英的粉尘一样，可诱发大鼠肺泡蛋白沉积症的发生。
