促进 NAD：银屑病中 Th17 细胞代谢重编程的机会。
Boosting NAD: An opportunity for metabolic reprogramming of Th17 cells in psoriatic disease.
机构信息
Department of Translational Medicine, University of Ferrara, via Luigi Borsari 46, 44121 Ferrara, Italy.
出版信息
Cell Rep Med. 2023 Sep 19;4(9):101163. doi: 10.1016/j.xcrm.2023.101163.
Abstract
Metabolic reprogramming of CD4 T cells has become an opportunity for adjunctive therapies. Here, Han et al. show that boosting NAD blunts systemic Th17 responses and increases antioxidant pathways through arginine and fumarate-mediated activation of NRF2 transcription factor.
摘要
CD4 T 细胞的代谢重编程已成为辅助治疗的机会。在这里，Han 等人表明，提高 NAD 水平可通过精氨酸和富马酸介导的 NRF2 转录因子激活来减轻全身性 Th17 反应并增加抗氧化途径。
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