Department of Physical Therapy, Rehabilitation Science and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA.
College of Rehabilitative Sciences, University of St. Augustine for Health Sciences, Miami, 800 S. Douglas Road, Suite 149, Coral Gables, FL, 33134, USA.
Exp Brain Res. 2023 Dec;241(11-12):2605-2616. doi: 10.1007/s00221-023-06705-7. Epub 2023 Sep 20.
This study investigated the impact of type 2 diabetes and diabetic peripheral neuropathy on grip force control during object manipulation. The study included three age-matched groups: type 2 diabetes alone (n = 11), type 2 diabetes with neuropathy (n = 13), and healthy controls (n = 12). Grip force control variables derived from lifting and holding an experimental cup were the ratio between grip force and load forces during lifting (GFR), latency 1 and latency 2, which represented the time between the object's grip and its lift-off from the table, and the period between object's lift-off and the grip force peak, respectively; time lag, which denoted the time difference between the grip and load force peaks during the lifting phase, and finally static force, which was the grip force average during the holding phase. Grip force control variables were compared between groups using one-way ANOVA and Kruskal-Wallis test. Post-hoc analysis was used to compare differences between groups. GFR and latency 1 showed significant differences between groups; the type 2 diabetes with neuropathy group showed larger GFR than the type 2 diabetes alone and healthy control groups. The latency 1was longer for the group with neuropathy in comparison with the health control group. There were no significant differences between groups for latency 2, time lag, and static force. Our results showed impaired GFR and latency 1 in participants with type 2 diabetes with neuropathy while the time lag was preserved. People with type 2 diabetes alone might not have any deficits in grip force control. Higher grip forces might expose people with type 2 diabetes and diabetic peripheral neuropathy to the risk of fatigue and injuring their hands. Future studies should investigate strategies to help people with type 2 diabetes with neuropathy adjust grip forces during object manipulation.
本研究探讨了 2 型糖尿病和糖尿病周围神经病变对物体操作过程中握力控制的影响。研究包括三组年龄匹配的人群：单纯 2 型糖尿病组（n=11）、2 型糖尿病合并周围神经病变组（n=13）和健康对照组（n=12）。从提起和握持实验杯中得出的握力控制变量包括提升过程中握力与负载力的比值（GFR）、潜伏期 1 和潜伏期 2，分别表示物体被抓住到离开桌面的时间，以及物体离开桌面到握力峰值之间的时间段；时滞，它表示提升阶段握力和负载力峰值之间的时间差；最后是静电力，它是握持阶段的平均握力。使用单向方差分析和克鲁斯卡尔-沃利斯检验比较组间握力控制变量。采用事后分析比较组间差异。GFR 和潜伏期 1 组间差异有统计学意义；与单纯 2 型糖尿病组和健康对照组相比，合并周围神经病变的 2 型糖尿病组的 GFR 更大。与健康对照组相比，周围神经病变组的潜伏期 1 更长。潜伏期 2、时滞和静电力组间无显著差异。我们的结果表明，合并周围神经病变的 2 型糖尿病患者的 GFR 和潜伏期 1 受损，而时滞保持不变。单纯 2 型糖尿病患者的握力控制可能没有任何缺陷。更高的握力可能会使 2 型糖尿病和糖尿病周围神经病变患者面临疲劳和手部受伤的风险。未来的研究应该探讨帮助 2 型糖尿病合并周围神经病变患者在物体操作过程中调整握力的策略。
