Department of Mathematics, University of Gujrat, Gujrat, 50700, Pakistan.
School of Life and Pharmaceutical Sciences, Dalian University of Technology, Dalian, China.
Sci Rep. 2023 Sep 20;13(1):15588. doi: 10.1038/s41598-023-42795-7.
This article scrutinizes blood circulation through an artery having magnetized hybrid nanoparticles (silver and gold) with multiple stenoses at the outer walls and erratic thrombus of different radii at the center. In the realm of biomedical innovation, magnetized hybrid nanoparticles emerge as a captivating frontier. These nanoparticles, amalgamating diverse materials, exhibit magnetic properties that engender novel prospects for targeted drug delivery, medical imaging enhancement, and therapeutic interventions. The study was carried out employing modern bio-fluid dynamics (BFD) software. In this iterative procedure, a second-order finite difference approach is used to solve the governing equations with 0.005 tolerance. The experiment is performed on a blood conduit with mild stenosis assumptions, and expressions of temperature, resistance impedance to flow, velocity, wall shear stress, and pressure gradient are generated by employing related boundary conditions. No one has ever attempted to acquire the remedial impact of an induced magnetic field and hybrid nanoparticles on the bloodstream in a tapering artery containing multiple stenoses on the outside walls and multi-thrombus at the center using 3-D bio-fluid simulation. Furthermore, the study's findings are unique, and these computational discoveries were not previously published by any researcher. The findings suggest that hybrid nanoparticles can be used as medication carriers to reduce the impact of thrombosis and stenosis-induced resistance to blood flow or coagulation-related factors.
本文研究了在外壁有多处分叉狭窄及中心处有不同半径血栓的动脉中,带有磁性混合纳米粒子(金和银)的血液流动。在生物医学创新领域,磁性混合纳米粒子是一个引人注目的前沿领域。这些纳米粒子结合了多种材料,具有磁性,为靶向药物输送、医学成像增强和治疗干预带来了新的前景。该研究使用了现代生物流体动力学(BFD)软件进行。在这个迭代过程中,使用二阶有限差分方法求解控制方程,公差为 0.005。该实验在假设轻度狭窄的血液导管上进行,并通过采用相关的边界条件生成温度、流动阻力阻抗、速度、壁面剪切应力和压力梯度的表达式。没有人曾经尝试过使用三维生物流体模拟来获得在包含外壁多处狭窄和中心处有多血栓的变窄动脉中,外加磁场和混合纳米粒子对血流的治疗影响。此外,该研究的结果是独特的,这些计算发现以前没有任何研究人员发表过。研究结果表明,混合纳米粒子可用作药物载体,以减少血栓形成和狭窄引起的血流阻力或与凝血相关的因素的影响。