Park Sungwoo, Jeong Eun Jeong, Kang Jung Hun, Lee Gyeong-Won, Go Se-Il, Lee Dong-Hyun, Koh Eun-Ha
Division of Hematology and Oncology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Gyeongsang National University, Jinju 52727, South Korea.
Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon 52828, South Korea.
World J Clin Cases. 2023 Sep 16;11(26):6200-6205. doi: 10.12998/wjcc.v11.i26.6200.
Mixed-phenotype acute leukemia (MPAL) is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid antigens. However, consensus regarding the ideal management strategy for MPAL is yet to be established, owing to its rarity.
A 55-year-old male was diagnosed with T/myeloid MPAL. Vincristine, prednisolone, daunorubicin, and L-asparaginase were administered as induction chemotherapy. Septic shock occurred 10 days after induction, and bone marrow examination following recovery from sepsis revealed refractory disease. Venetoclax and decitabine were administered as chemotherapy-free induction therapy to reduce the infection risk. There were no serious infections, including febrile neutropenia, at the end of the treatment. After receiving two additional cycles of venetoclax/decitabine, the patient underwent haploidentical peripheral blood stem-cell transplantation and achieved complete response (CR) to treatment.
CR was maintained in a patient with MPAL who underwent haploidentical peripheral blood stem-cell transplantation after additional venetoclax/decitabine cycles.
混合表型急性白血病（MPAL）的特征是急性未分化白血病，其原始细胞同时表达髓系和淋巴系抗原。然而，由于其罕见性，关于MPAL理想治疗策略的共识尚未达成。
一名55岁男性被诊断为T/髓系MPAL。给予长春新碱、泼尼松龙、柔红霉素和L-天冬酰胺酶进行诱导化疗。诱导化疗10天后发生感染性休克，败血症恢复后进行的骨髓检查显示为难治性疾病。给予维奈克拉和地西他滨作为无化疗诱导治疗以降低感染风险。治疗结束时未发生包括发热性中性粒细胞减少在内的严重感染。在接受另外两个周期的维奈克拉/地西他滨治疗后，患者接受了单倍体相合外周血干细胞移植，并实现了治疗完全缓解（CR）。
一名MPAL患者在接受额外的维奈克拉/地西他滨周期治疗后进行了单倍体相合外周血干细胞移植，维持了完全缓解（CR）。
