Kao Leslie E, Stover Diane
Pulmonary Medicine Service Memorial Sloan Kettering Cancer Center New York New York USA.
Respirol Case Rep. 2023 Sep 19;11(10):e01223. doi: 10.1002/rcr2.1223. eCollection 2023 Oct.
Radiation recall is an unpredictable, poorly understood inflammatory reaction within the confines of previously irradiated tissue that occurs following exposure to a systemic agent. In this article, we will focus on a subcategory of radiation recall, called radiation recall pneumonitis (RRP), precipitated by immune checkpoint inhibitors (ICI). Historically, RRP can develop weeks to years after radiation treatment to the lung, most commonly after receiving certain chemotherapeutic agents, but more recently has been recognized in association with immunotherapy agents (ICIs). Up until now, RRP following exposure to ICIs has been described in patients who have received radiation to the lung itself. Here we present three cases of RRP in patients who received radiation to areas adjacent to the lung parenchyma, and developed pulmonary infiltrates in an area adjacent to the radiation field while on ICI therapy. Since ICI induced RRP is treatable and steroid sensitive, early recognition and treatment are important.
放射性回忆反应是一种不可预测、了解甚少的炎症反应，发生在先前接受过放疗的组织范围内，是在接触全身用药后出现的。在本文中，我们将重点关注放射性回忆反应的一个亚类，称为放射性回忆性肺炎（RRP），它由免疫检查点抑制剂（ICI）诱发。从历史上看，RRP可在肺部放疗后数周或数年发生，最常见于接受某些化疗药物后，但最近已认识到其与免疫治疗药物（ICI）有关。到目前为止，接触ICI后发生的RRP已在接受过肺部放疗的患者中有所描述。在此，我们报告3例RRP患者，这些患者接受了肺部实质邻近区域的放疗，并在接受ICI治疗期间，在放疗野邻近区域出现了肺部浸润。由于ICI诱发的RRP是可治疗的且对类固醇敏感，早期识别和治疗很重要。
