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首次发作躁狂或精神病之前的就医途径中的种族差异:一项历史性队列前驱研究。

Racial differences in pathways to care preceding first episode mania or psychosis: a historical cohort prodromal study.

作者信息

Gardea-Resendez Manuel, Ortiz-Orendain Javier, Miola Alessandro, Fuentes Salgado Manuel, Ercis Mete, Coombes Brandon J, Gruhlke Peggy M, Bostwick J Michael, Michel Ian, Vande Voort Jennifer L, Ozerdem Aysegul, McKean Alastair, Frye Mark A, Taylor-Desir Monica

机构信息

Department of Psychiatry, Universidad Autónoma de Nuevo León, Monterrey, Mexico.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.

出版信息

Front Psychiatry. 2023 Sep 4;14:1241071. doi: 10.3389/fpsyt.2023.1241071. eCollection 2023.

Abstract

BACKGROUND

There is evidence suggesting racial disparities in diagnosis and treatment in bipolar disorder (BD) and schizophrenia (SZ). The purpose of this study is to compare psychiatric diagnoses and psychotropic use preceding a first episode of mania (FEM) or psychosis (FEP) in racially diverse patients.

METHODS

Using a comprehensive medical records linkage system (Rochester Epidemiology Project, REP), we retrospectively identified individuals diagnosed with BD or SZ and a documented first episode of mania or psychosis. Illness trajectory before FEP/FEM were characterized as the time from first visit for a mental health complaint to incident case. Pathways to care and clinical events preceding FEP/FEM were compared based on subsequent incident case diagnosis (BD or SZ) and self-reported race (White vs. non-White).

RESULTS

A total of 205 (FEM = 74; FEP = 131) incident cases were identified in the REP. Duration of psychiatric antecedents was significantly shorter in non-White patients, compared to White patients (2.2 ± 4.3 vs. 7.4 ± 6.6 years;  < 0.001) with an older age at time of first visit for a mental health complaint (15.7 ± 6.3 vs. 11.1 ± 6.0 years;  = 0.005). There were no significant differences by race in FEM pathway to care or age of first seeking mental health. Overall non-White patients had lower rates of psychotropic use.

CONCLUSION

These data are unable to ascertain reasons for shorter duration of psychiatric antecedents and later age of seeking care, and more broadly first age of initial symptom presentation. If symptoms are confirmed to be earlier than first time seeking care in both groups, it would be important to identify barriers that racial minorities face to access timely psychiatric care and optimize early intervention strategies.

摘要

背景

有证据表明双相情感障碍(BD)和精神分裂症(SZ)在诊断和治疗方面存在种族差异。本研究的目的是比较不同种族患者在首次躁狂发作(FEM)或首次精神病发作(FEP)之前的精神科诊断和精神药物使用情况。

方法

使用综合医疗记录链接系统(罗切斯特流行病学项目,REP),我们回顾性地确定了被诊断为BD或SZ且有记录的首次躁狂发作或精神病发作的个体。FEP/FEM之前的疾病轨迹被描述为从首次因心理健康问题就诊到确诊病例的时间。根据后续确诊病例诊断(BD或SZ)和自我报告的种族(白人vs.非白人)比较FEP/FEM之前的就医途径和临床事件。

结果

在REP中总共确定了205例确诊病例(FEM = 74例;FEP = 131例)。与白人患者相比,非白人患者的精神科前驱期明显更短(2.2±4.3年 vs. 7.4±6.6年;<0.001),首次因心理健康问题就诊时年龄更大(15.7±6.3岁 vs. 11.1±6.0岁;=0.005)。在FEM的就医途径或首次寻求心理健康治疗的年龄方面,种族之间没有显著差异。总体而言,非白人患者的精神药物使用率较低。

结论

这些数据无法确定精神科前驱期较短和寻求治疗年龄较晚的原因,更广泛地说,无法确定初始症状首次出现的年龄。如果两组症状被证明确实早于首次寻求治疗的时间,那么识别少数族裔在获得及时精神科护理方面面临的障碍并优化早期干预策略将非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e955/10507622/bf587ee7f082/fpsyt-14-1241071-g001.jpg

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