从正常血压大鼠和自发性高血压大鼠分离出的灌注心脏对缺血的功能和代谢反应。

Functional and metabolic responses to ischemia in the perfused heart isolated from normotensive and spontaneously hypertensive rats.

作者信息

Haneda T, Ichihara K, Abiko Y, Onodera S

出版信息

Jpn Circ J. 1986 Jul;50(7):607-13. doi: 10.1253/jcj.50.607.

DOI:10.1253/jcj.50.607

Abstract

The difference between normotensive rats (WKY) and spontaneously hypertensive rats (SHR) in functional and metabolic responses to ischemia was studied. Systolic arterial blood pressure of SHR (171.2 +/- 2.9 mmHg) was significantly higher than that of WKY (135.3 +/- 1.2 mmHg), and the left ventricular mass of SHR was larger than that of WKY. Hearts isolated from either WKY or SHR were perfused by the working heart technique. Ischemia was induced by lowering the afterload pressure of the working heart. Ischemia produced cardiac arrest, and decreased the tissue levels of adenosine triphosphate and creatine phosphate in both WKY and SHR. Recovery of mechanical function of the heart during reperfusion following ischemia in SHR was better than that in WKY, while recovery of the high-energy phosphates level in SHR was less prominent than in WKY. It is postulated that hypertension has a deleterious effect on myocardial energy metabolism in ischemic heart, even when cardiac mechanical function is maintained.

摘要

研究了正常血压大鼠（WKY）和自发性高血压大鼠（SHR）在缺血功能和代谢反应方面的差异。SHR的收缩动脉血压（171.2±2.9 mmHg）显著高于WKY（135.3±1.2 mmHg），且SHR的左心室质量大于WKY。采用工作心脏技术灌注从WKY或SHR分离出的心脏。通过降低工作心脏的后负荷压力诱导缺血。缺血导致心脏骤停，并降低了WKY和SHR的三磷酸腺苷和磷酸肌酸组织水平。SHR缺血后再灌注期间心脏机械功能的恢复优于WKY，而SHR中高能磷酸盐水平的恢复不如WKY显著。据推测，高血压对缺血心脏的心肌能量代谢有有害影响，即使心脏机械功能得以维持。