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哌醋甲酯过量导致的死亡。

Fatality resulting from methylphenidate overdose.

作者信息

Levine B, Caplan Y H, Kauffman G

出版信息

J Anal Toxicol. 1986 Sep-Oct;10(5):209-10. doi: 10.1093/jat/10.5.209.

DOI:10.1093/jat/10.5.209
PMID:3773482
Abstract

A case involving an accidental overdose fatality resulting from an intravenous injection of crushed Ritalin (methylphenidate) tablets is presented. The drug was quantified by gas chromatography/nitrogen-phosphorus detection and confirmed by gas chromatography/mass spectrometry. Concentrations of drug were as follows: blood, 2.8 mg/L; bile, 5.7 mg/L; kidney, 3.0 mg/kg; liver, 2.1 mg/kg; and stomach contents, 1.6 mg total. Other drugs and volatile substances were not detected.

摘要

本文介绍了一例因静脉注射碾碎的利他林(哌醋甲酯)片剂导致意外过量致死的案例。通过气相色谱/氮磷检测对药物进行定量,并通过气相色谱/质谱法进行确认。药物浓度如下:血液,2.8毫克/升;胆汁,5.7毫克/升;肾脏,3.0毫克/千克;肝脏,2.1毫克/千克;胃内容物,总量1.6毫克。未检测到其他药物和挥发性物质。

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1
Fatality resulting from methylphenidate overdose.哌醋甲酯过量导致的死亡。
J Anal Toxicol. 1986 Sep-Oct;10(5):209-10. doi: 10.1093/jat/10.5.209.
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A reproducible gas chromatographic mass spectrometric assay for low levels of methylphenidate and ritalinic acid in blood and urine.一种用于检测血液和尿液中低水平哌醋甲酯和利他林酸的可重现气相色谱-质谱分析法。
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Negative ion chemical ionization for the determination of methylphenidate in human plasma by stable isotope dilution gas chromatography/mass spectrometry.负离子化学电离结合稳定同位素稀释气相色谱/质谱法测定人血浆中的哌醋甲酯。
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Gas chromatographic-mass spectrometric analysis of methylphenidate and p-hydroxymethylphenidate using deuterated internal standards.
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Gas-chromatographic quantification of methylphenidate in plasma with use of solid-phase extraction and nitrogen-sensitive detection.采用固相萃取和氮敏检测法对血浆中哌甲酯进行气相色谱定量分析。
Clin Chem. 1984 Aug;30(8):1374-7.

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Evolution of stimulants to treat ADHD: transdermal methylphenidate.治疗注意力缺陷多动障碍(ADHD)的兴奋剂的演变:透皮哌甲酯。
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