绝经阶段对缺血再灌注损伤内皮抵抗能力的差异。
Menopausal stage differences in endothelial resistance to ischemia-reperfusion injury.
机构信息
Integrative and Biomedical Physiology, Huck Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Kinesiology Department, The Pennsylvania State University, University Park, Pennsylvania, USA.
出版信息
Physiol Rep. 2023 Sep;11(18):e15768. doi: 10.14814/phy2.15768.
BACKGROUND
In postmenopausal women, reduced ovarian function precedes endothelial dysfunction and attenuated endothelial resistance to ischemia-reperfusion (IR) injury. We hypothesized that IR injury would lower endothelial function, with premenopausal women demonstrating the greatest protection from injury, followed by early, then late postmenopausal women.
METHODS
Flow-mediated dilation (FMD) was assessed at baseline and following IR injury in premenopausal (n = 11), early (n = 11; 4 ± 1.6 years since menopause), and late (n = 11; 15 ± 5.5 years since menopause) postmenopausal women.
RESULTS
There were significant group differences in baseline FMD (p = 0.007); post hoc analysis revealed a similar resting FMD between premenopausal (7.8% ± 2.1%) and early postmenopausal (7.1% ± 2.7%), but significantly lower FMD in late postmenopausal women (4.5% ± 2.3%). Results showed an overall decline in FMD after IR injury (p < 0.001), and a significant condition*time interaction (p = 0.048), with early postmenopausal women demonstrating the most significant decline in FMD following IR.
CONCLUSION
Our findings indicate that endothelial resistance to IR injury is attenuated in healthy early postmenopausal women.
背景
在绝经后妇女中，卵巢功能下降先于内皮功能障碍，并减弱了内皮对缺血再灌注（IR）损伤的抵抗力。我们假设 IR 损伤会降低内皮功能，而绝经前女性受到的损伤最小，其次是早期绝经后女性，然后是晚期绝经后女性。
方法
在绝经前（n=11）、早期（n=11；绝经后 4±1.6 年）和晚期（n=11；绝经后 15±5.5 年）绝经后女性中，在基线和 IR 损伤后评估血流介导的扩张（FMD）。
结果
基线 FMD 存在显著的组间差异（p=0.007）；事后分析显示，绝经前（7.8%±2.1%）和早期绝经后（7.1%±2.7%）女性的静息 FMD 相似，但晚期绝经后女性的 FMD 显著降低（4.5%±2.3%）。结果显示，IR 损伤后 FMD 总体下降（p<0.001），且条件*时间交互作用显著（p=0.048），早期绝经后女性 FMD 下降最显著。
结论
我们的研究结果表明，健康的早期绝经后女性对 IR 损伤的内皮抵抗能力减弱。
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