Kazak Lawrence
Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
iScience. 2023 Sep 6;26(10):107843. doi: 10.1016/j.isci.2023.107843. eCollection 2023 Oct 20.
Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy dissipating pathways have been identified in adipose tissue and muscle. The molecular effectors of some of these pathways have been identified, but much is still left to be learned about their regulation. Understanding the molecular underpinnings of metabolic inefficiency in adipose tissue and muscle is required if these pathways are to be therapeutically targeted in the context of obesity and obesity-accelerated diseases.
促进食欲抑制的药物疗法的最新进展已显示出显著的体重减轻。针对能量消耗的疗法相对滞后，因此尚未发现有任何一种疗法对维持负能量平衡以实现体重减轻是安全有效的。在脂肪组织和肌肉中已确定了多种能量消耗途径。其中一些途径的分子效应器已被确定，但关于它们的调节仍有许多有待了解。如果要在肥胖症和肥胖加速疾病的背景下对这些途径进行治疗靶向，就需要了解脂肪组织和肌肉中代谢低效的分子基础。
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