胞磷胆碱对巴氏指数的影响：严重和中度脑损伤。
Citicoline on the Barthel Index: Severe and moderate brain injury.
机构信息
Department of Neurosurgery, School of Medicine, Neurosciences Research Center, Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Neurosurgery, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Indian J Pharmacol. 2023 Jul-Aug;55(4):223-228. doi: 10.4103/ijp.ijp_570_21.
INTRODUCTION
Traumatic brain injury (TBI) is a paramount factor in mortality and morbidity. The clinical trials conducted to investigate the efficacy of neuroprotective agents, such as citicoline, as a therapeutic alternative for TBI have presented divergent findings. Therefore, this study aimed to evaluate and compare citicoline's effect on the Barthel Index in patients with severe and moderate brain injury.
MATERIALS AND METHODS
The study is a randomized clinical trial. Patients in the case group (35 patients) were treated with citicoline and the control group (34 patients) received a placebo. Data were analyzed using SPSS 16 software.
RESULTS
The results showed that changes in the Glasgow Coma Scale, changes in quadriceps muscle force score, Barthel Index score changes, achieving the status without intubation, and spontaneous breathing in patients treated with citicoline were not a statistically significant difference in the two groups (P > 0.05).
CONCLUSION
Findings revealed that citicoline did not impact the recovery process of severe and moderate TBI patients.
简介
创伤性脑损伤（TBI）是导致死亡率和发病率的主要因素。已开展临床试验以研究胞磷胆碱等神经保护剂作为 TBI 治疗选择的疗效，但结果存在差异。因此，本研究旨在评估和比较胞磷胆碱对严重和中度脑损伤患者 Barthel 指数的影响。
材料与方法
本研究为一项随机临床试验。病例组（35 例）患者接受胞磷胆碱治疗，对照组（34 例）患者接受安慰剂。使用 SPSS 16 软件进行数据分析。
结果
结果表明，两组患者格拉斯哥昏迷量表变化、股四头肌肌力评分变化、Barthel 指数评分变化、达到无需插管状态以及自主呼吸的比例差异均无统计学意义（P＞0.05）。
结论
研究结果表明，胞磷胆碱对严重和中度 TBI 患者的恢复过程没有影响。
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