Çağlar Hanife Tuğçe, Pekcan Sevgi, Yılmaz Aslı İmran, Ünal Gökçen, Ercan Fatih, Savaş Suat, Akcan Özge Metin, Ünsaçar Mahmut Ziya, Ünsaçar Kübra, Özdemir Mehmet
Department of Pediatric Pulmonology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
Department of Pediatric Infectious Diseases, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
Pediatr Pulmonol. 2023 Dec;58(12):3582-3587. doi: 10.1002/ppul.26696. Epub 2023 Sep 22.
Only a few studies have investigated the frequency and severity of respiratory syncytial virus (RSV) infections after the end of the pandemic regulations. This study aims to investigate the frequency and severity of RSV infections before, during, and after the pandemic in Turkey.
Patients under 18 years of age and those who tested positive for RSV between April 2018 and March 2023 were retrospectively reviewed. All patients were divided into three groups (pre-COVID-19, COVID-19, and post-COVID-19) according to admission date. Among inpatients, data were compared between the three groups to determine the impact of the pandemic on RSV epidemiology and clinical outcomes.
A total of 9567 patients were tested for RSV, of which 1073 (11.2%) were positive and included in the study. Hospitalization occurred in 447 (41.7%) patients. Inpatients were younger than outpatients (p < .000). Among the three inpatient pandemic groups, clinical outcomes were statistically significantly worse in the post-COVID-19 group than in the other two groups. SpO was lower (p < .000), inhaled salbutamol requirement was higher (p < .000), length of stay was longer (p = .031), and ICU admission was higher (p = .023).
Although the RSV trend changed within 2 years after the COVID-19 outbreak, it returned to its usual seasonality last year. After the repeal of all COVID-19 measures and the normal life began, the number of RSV-positive patients and RSV-related hospitalizations increased, and the clinical outcomes of RSV worsened. This may be a result of decreased herd immunity due to a change in society's attitude toward epidemic diseases.
只有少数研究调查了大流行规定结束后呼吸道合胞病毒（RSV）感染的频率和严重程度。本研究旨在调查土耳其大流行之前、期间和之后RSV感染的频率和严重程度。
回顾性分析2018年4月至2023年3月期间18岁以下且RSV检测呈阳性的患者。根据入院日期将所有患者分为三组（新冠疫情前、新冠疫情期间、新冠疫情后）。在住院患者中，比较三组之间的数据，以确定大流行对RSV流行病学和临床结局的影响。
共有9567名患者接受了RSV检测，其中1073名（11.2%）呈阳性并纳入研究。447名（41.7%）患者住院。住院患者比门诊患者年轻（p<0.000）。在三个住院大流行组中，新冠疫情后组的临床结局在统计学上比其他两组更差。血氧饱和度较低（p<0.000），吸入沙丁胺醇的需求较高（p<0.000），住院时间较长（p=0.031），入住重症监护病房的比例较高（p=0.023）。
尽管RSV趋势在新冠疫情爆发后的2年内发生了变化，但去年又恢复到了其通常的季节性。在所有新冠疫情措施取消且生活恢复正常后，RSV阳性患者数量和与RSV相关的住院人数增加，RSV的临床结局恶化。这可能是由于社会对流行病态度的改变导致群体免疫力下降的结果。
