Department of Orthopedics and Traumatology, Erzincan University, Faculty of Medicine, Erzincan, Turkey.
Department of Orthopedics and Traumatology, İstanbul Research and Training Hospital, İstanbul, Turkey.
Acta Orthop Traumatol Turc. 2023 Sep;57(5):204-208. doi: 10.5152/j.aott.2023.22132.
The aim of this study was to assess the effects of tranexamic acid on fracture healing in the rat tibia closed fracture model.
Sixty-four male Sprague-Dawley rats were included in this study, where closed fracture and intramedullary nailing were performed on their right tibial diaphyses. They were divided into 2 main groups, the experimental group, which was given weekly tranexamic acid injections, and the control group, which received no additional treatment. Eight rats from each group were sacrificed and evaluated for fracture healing at the first experimental group and control group, second experimental group and control group, third experimental group and control group, and fourth experimental group and control group weeks. Fracture healing was radiologically assessed according to the "Spencer Index" and "Lane and Sandhu Scoring System," and histologically evaluated according to the scoring system devised by Huo et al. Results: According to the Spencer Index, the mean union score was statistically significantly higher in the E3 group than in the third con- trol group (P = .014). Furthermore, the mean union score was statistically significantly higher in the fourth experimental group compared to the fourth control group (P=.047). According to the Lane and Sandhu Scoring System, only the mean union scores of the E3-4 groups were statistically significantly higher than the mean union scores of the C3-4 groups (P=.048). There was no histological difference between groups in terms of union, according to the criteria defined by Huo et al (P > .05).
This study showed us that repeated intravenous administrations of tranexamic acid had no negative effect on fracture heal- ing in the rat tibia fracture model. Although tranexamic acid demonstrated better radiological healing in the late period, it had no effect on histological union.
本研究旨在评估氨甲环酸对大鼠胫骨闭合性骨折模型骨折愈合的影响。
本研究纳入 64 只雄性 Sprague-Dawley 大鼠，对其右侧胫骨骨干进行闭合性骨折和髓内钉固定。将它们分为 2 个主要组，实验组每周给予氨甲环酸注射，对照组不给予额外治疗。每组有 8 只大鼠被处死，并在第 1 组和对照组、第 2 组和对照组、第 3 组和对照组、第 4 组和对照组分别进行 4 周的骨折愈合评估。骨折愈合情况通过“Spencer 指数”和“Lane 和 Sandhu 评分系统”进行放射学评估，并通过 Huo 等人制定的评分系统进行组织学评估。
根据 Spencer 指数，E3 组的平均愈合评分明显高于第 3 对照组（P=0.014）。此外，第四实验组的平均愈合评分明显高于第四对照组（P=0.047）。根据 Lane 和 Sandhu 评分系统，只有 E3-4 组的平均愈合评分明显高于 C3-4 组（P=0.048）。根据 Huo 等人定义的标准，各组之间在愈合方面没有组织学差异（P＞0.05）。
本研究表明，重复静脉内给予氨甲环酸对大鼠胫骨骨折模型的骨折愈合没有负面影响。尽管氨甲环酸在后期显示出更好的影像学愈合，但对组织学愈合没有影响。
