在清醒的普通猕猴中使用超高场 fMRI 进行体内功能脑图谱绘制。
In vivo functional brain mapping using ultra-high-field fMRI in awake common marmosets.
机构信息
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
出版信息
STAR Protoc. 2023 Dec 15;4(4):102586. doi: 10.1016/j.xpro.2023.102586. Epub 2023 Sep 21.
The common marmoset (Callithrix jacchus) is gaining attention in the field of cognitive neuroscience. The development of an effective protocol for fMRI data acquisition in awake marmosets is a key factor in developing reliable comparative studies. Here, we describe a protocol to obtain fMRI data in awake marmosets using auditory and visual stimulation. We describe steps for surgical and anesthesia procedures, MRI training, and positioning the marmosets within an MRI-compatible body restraint. We then detail fMRI scanning and preprocessing of functional images. For complete details on the use and execution of this protocol, please refer to Jafari et al. (2023)..
普通狨猴（Callithrix jacchus）在认知神经科学领域受到关注。开发一种有效的功能磁共振成像（fMRI）数据采集方案，对于开展可靠的比较研究至关重要。在此，我们描述了一种在清醒狨猴中使用听觉和视觉刺激获取 fMRI 数据的方案。我们描述了手术和麻醉程序、MRI 训练以及将狨猴置于 MRI 兼容的身体约束装置内的步骤。然后，我们详细介绍了 fMRI 扫描和功能图像的预处理。有关该方案使用和执行的完整详细信息，请参考 Jafari 等人（2023）的研究。
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