Dureux Audrey, Zanini Alessandro, Jafari Azadeh, Everling Stefan
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, Ontario N6A 5K8, Canada,
Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, Ontario N6A 5K8, Canada.
J Neurosci. 2025 Apr 9;45(15):e0651242025. doi: 10.1523/JNEUROSCI.0651-24.2025.
Auditory deficits are a well-known symptom in neuropsychiatric disorders such as schizophrenia. The noncompetitive -methyl-d-aspartate receptor antagonist ketamine has been used to model sensory and cognitive deficits in nonhuman primates, but its whole-brain effects remain largely unknown. Here we employed ultra-high field functional magnetic resonance imaging at 9.4 T in awake male and female marmoset monkeys () to compare brain activations to conspecific vocalizations, scrambled vocalizations, and nonvocal sounds following the administration of a subanesthetic dose of ketamine. Our findings reveal a broad suppression of activations across auditory regions following ketamine compared with saline. Additionally, we observed differential effects depending on the type of sound, with notable changes in the mediodorsal thalamus and anterior cingulate cortex, particularly during the processing of vocalizations. These findings suggest a potential overlap between the effects of ketamine and neural disruptions observed in schizophrenia, particularly affecting vocalization processing.
听觉缺陷是精神分裂症等神经精神疾病中一种众所周知的症状。非竞争性N-甲基-D-天冬氨酸受体拮抗剂氯胺酮已被用于模拟非人类灵长类动物的感觉和认知缺陷，但其对全脑的影响在很大程度上仍不为人知。在这里，我们在9.4T的超高场功能磁共振成像中，对清醒的雄性和雌性狨猴（Callithrix jacchus）进行研究，以比较在给予亚麻醉剂量的氯胺酮后，大脑对同种发声、加扰发声和非发声声音的激活情况。我们的研究结果显示，与生理盐水相比，氯胺酮给药后听觉区域的激活受到广泛抑制。此外，我们观察到根据声音类型的不同会有不同的影响，在丘脑背内侧核和前扣带回皮质有显著变化，特别是在发声处理过程中。这些发现表明，氯胺酮的作用与精神分裂症中观察到的神经功能紊乱之间可能存在重叠，特别是对发声处理的影响。
