Hropot M, Sörgel F, Mutschler E
Naunyn Schmiedebergs Arch Pharmacol. 1986 Aug;333(4):457-61. doi: 10.1007/BF00500025.
The interaction between furosemide on the one hand and hydrochlorothiazide, tizolemide, amiloride and triamterene on the other was studied by clearance and micropuncture techniques in rats. Simultaneous administration of furosemide with hydrochlorothiazide and tizolemide distinctly increased the natriuresis compared to that induced by furosemide alone, whereas the potassium excretion diminished. In contrast, amiloride and triamterene primarily decreased furosemide-induced fractional potassium excretion by about 30%, whereas sodium excretion increased only slightly compared to that produced by furosemide alone. Hydrochlorothiazide and triamterene significantly decreased furosemide secretion and changed its pharmacokinetics. Furosemide plasma concentration increased, thus possibly prolonging the salidiuretic effect. Amiloride and tizolemide did not influence the secretion of furosemide at all.
通过清除率和微穿刺技术在大鼠中研究了速尿与氢氯噻嗪、替唑米特、氨氯吡咪和氨苯蝶啶之间的相互作用。与单独使用速尿相比，速尿与氢氯噻嗪和替唑米特同时给药显著增加了钠利尿作用，而钾排泄减少。相比之下，氨氯吡咪和氨苯蝶啶主要使速尿诱导的钾排泄分数降低约30%，而与单独使用速尿相比，钠排泄仅略有增加。氢氯噻嗪和氨苯蝶啶显著降低速尿分泌并改变其药代动力学。速尿血浆浓度升高，从而可能延长其利钠利尿作用。氨氯吡咪和替唑米特对速尿分泌完全没有影响。
