Sahoo Priyambada, Choudhary Piyush, Laha Suvra S, Dixit Ambesh, Mefford O Thompson
Advanced Materials and Devices (A-MAD) Laboratory, Department of Physics, Indian Institute of Technology (IIT) Jodhpur, Karwar, Jodhpur, Rajasthan, 342030, India.
Department of Materials Science & Engineering, Clemson University, Clemson, SC 29634, USA.
Chem Commun (Camb). 2023 Oct 10;59(81):12065-12090. doi: 10.1039/d3cc01637d.
Spinel ferrite-based magnetic nanomaterials have been investigated for numerous biomedical applications, including targeted drug delivery, magnetic hyperthermia therapy (MHT), magnetic resonance imaging (MRI), and biosensors, among others. Recent studies have found that zinc ferrite-based nanomaterials are favorable candidates for cancer theranostics, particularly for magnetic hyperthermia applications. Zinc ferrite exhibits excellent biocompatibility, minimal toxicity, and more importantly, exciting magnetic properties. In addition, these materials demonstrate a Curie temperature much lower than other transition metal ferrites. By regulating synthesis protocols and/or introducing suitable dopants, the Curie temperature of zinc ferrite-based nanosystems can be tailored to the MHT therapeutic window, , 43-46 °C, a range which is highly beneficial for clinical hyperthermia applications. Furthermore, zinc ferrite-based nanostructures have been extensively used in successful pre-clinical trials on mice models focusing on the synergistic killing of cancer cells involving magnetic hyperthermia and chemotherapy. This review provides a systematic and comprehensive understanding of the recent developments of zinc ferrite-based nanomaterials, including doped particles, shape-modified structures, and composites for magnetic hyperthermia applications. In addition, future research prospects involving pure ZnFeO and its derivative nanostructures have also been proposed.
基于尖晶石铁氧体的磁性纳米材料已被研究用于众多生物医学应用，包括靶向药物递送、磁热疗（MHT）、磁共振成像（MRI）和生物传感器等。最近的研究发现，基于锌铁氧体的纳米材料是癌症诊疗的理想候选材料，特别是在磁热疗应用方面。锌铁氧体具有优异的生物相容性、极低的毒性，更重要的是，具有令人兴奋的磁性。此外，这些材料的居里温度远低于其他过渡金属铁氧体。通过调节合成方案和/或引入合适的掺杂剂，基于锌铁氧体的纳米系统的居里温度可以调整到磁热疗治疗窗口，即43 - 46°C，这个范围对临床热疗应用非常有利。此外，基于锌铁氧体的纳米结构已广泛应用于针对小鼠模型的成功临床前试验，重点是涉及磁热疗和化疗的癌细胞协同杀伤。本综述对基于锌铁氧体的纳米材料的最新进展提供了系统而全面的理解，包括用于磁热疗应用的掺杂颗粒、形状改性结构和复合材料。此外，还提出了涉及纯ZnFeO及其衍生纳米结构的未来研究前景。
