Corrone Michelle, Nanev Aleshia, Amato Isabella, Bicknell Rowena, Piantella Stefan, Maruff Paul, van den Buuse Maarten, Wright Bradley J
School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia.
Cogstate Ltd, Melbourne, Victoria, Australia.
Eur J Neurosci. 2023 Oct;58(8):3903-3916. doi: 10.1111/ejn.16153. Epub 2023 Sep 23.
The val66met polymorphism of the brain-derived neurotrophic factor (BDNF) gene has been identified as a potential moderator for the relationship between chronic stress and executive functioning. However, whether the presence of the met allele increases cognitive vulnerability or resilience to stress has yet to be determined. Given the established effects of autonomic activity and psychological arousal on executive functioning, in the present study, 56 healthy university students completed self-report measures of chronic stress, positive arousal (vigour) and negative arousal (anxiety) and measured heart-rate variability to quantify autonomic activity. Participants then completed a cognitive test battery that measured attention, decision-making, visual learning and working memory. Regression analyses demonstrated that Val/met participants performed better on attention and working memory tasks than Val/val participants, but no differences were seen in decision-making and visual learning. Further, Val/met participants were protected from stress-related differences in attention seen in Val/val participants. Val66met was not associated with physiological or psychological arousal. This study demonstrates that val66met plays an important but selective role in cognitive performance.
脑源性神经营养因子（BDNF）基因的Val66Met多态性已被确定为慢性应激与执行功能之间关系的潜在调节因素。然而，Met等位基因的存在是增加了认知易损性还是增强了对压力的恢复力，目前尚未确定。鉴于自主神经活动和心理唤醒对执行功能的既定影响，在本研究中，56名健康大学生完成了慢性应激、积极唤醒（活力）和消极唤醒（焦虑）的自我报告测量，并测量了心率变异性以量化自主神经活动。参与者随后完成了一组认知测试，测量注意力、决策、视觉学习和工作记忆。回归分析表明，Val/Met参与者在注意力和工作记忆任务上的表现优于Val/Val参与者，但在决策和视觉学习方面没有差异。此外，Val/Met参与者免受Val/Val参与者中出现的与压力相关的注意力差异的影响。Val66Met与生理或心理唤醒无关。这项研究表明，Val66Met在认知表现中起着重要但具有选择性的作用。
