Vita-Salute San Raffaele University, Via Olgettina 58, Milan 20132, Italy; Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy.
Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Piazza Pugliatti 1, Messina 98122, Italy.
Magn Reson Imaging Clin N Am. 2023 Nov;31(4):605-611. doi: 10.1016/j.mric.2023.06.006. Epub 2023 Aug 3.
The present systematic review and meta-analysis are focused on the diagnostic accuracy of PSMA PET/MRI in primary prostate cancer assessment. A literature search was conducted on the PubMed database using the terms "PSMA" AND "prostate cancer" or "prostate" AND "PET/MRI" or "PET MRI" or "PET-MRI" or "PET-MR" AND "primary" or "staging." Ten articles were eligible for analysis after applying the exclusion criteria. PET/MRI showed better diagnostic accuracy in detecting primary PCa compared to multiparametric (mp) MRI and PET alone. The pooled sensitivity and specificity of 68Ga-PSMA PET/MRI at the per-patient level were 0.976 (CI: 0.943-0.991) and 0.739 (CI: 0.437-0.912); respectively. PSMA PET/MRI has good sensitivity in detecting primary PCa, especially in patients with PIRADS 3 PCa.
本系统评价和荟萃分析专注于 PSMA PET/MRI 在原发性前列腺癌评估中的诊断准确性。使用术语“PSMA”和“前列腺癌”或“前列腺”和“PET/MRI”或“PET MRI”或“PET-MRI”或“PET-MR”和“primary”或“staging”在 PubMed 数据库中进行了文献检索。应用排除标准后，有 10 篇文章符合分析条件。与多参数 (mp) MRI 和单独 PET 相比，PET/MRI 显示出更好的诊断准确性，用于检测原发性前列腺癌。68Ga-PSMA PET/MRI 在每位患者水平的汇总敏感性和特异性分别为 0.976（CI：0.943-0.991）和 0.739（CI：0.437-0.912）。PSMA PET/MRI 在检测原发性前列腺癌方面具有良好的敏感性，特别是在 PIRADS 3 前列腺癌患者中。
