Gu Yebo, Jia Xin-Ming
Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China; Key Laboratory of Pathogen-Host Interactions of the Ministry of Education of China, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, China.
Trends Microbiol. 2023 Nov;31(11):1090-1092. doi: 10.1016/j.tim.2023.09.003. Epub 2023 Sep 22.
During viral infections, stimulator of interferon genes (STING) exerts a positive protective immune response. Chen et al. now shed light on the distinct role of STING in fungal infections. STING translocates to the phagosome to negatively regulate the immune response against Candida albicans infection through the inhibition of Src-involved Syk phosphorylation.
在病毒感染期间，干扰素基因刺激物（STING）发挥积极的保护性免疫反应。陈等人现在揭示了STING在真菌感染中的独特作用。STING易位至吞噬体，通过抑制与Src相关的Syk磷酸化来负向调节针对白色念珠菌感染的免疫反应。
