成年猫对侧小脑切除术后红核及相邻网状结构中γ-氨基丁酸能神经元可塑性的免疫组化证据

Immunohistochemical evidence of plasticity of gamma-aminobutyric acid neurons in the red nucleus and adjacent reticular formation after contralateral cerebellectomy in the adult cat.

作者信息

Vuillon-Cacciuttolo G, Bosler O, Nieoullon A

出版信息

Neurosci Lett. 1986 Oct 20;70(3):308-13. doi: 10.1016/0304-3940(86)90570-7.

Abstract

A comparative mapping of gamma-aminobutyric acid neurons identified by means of glutamic acid decarboxylase (GAD) immunohistochemistry was performed in the red nucleus (RN) in both intact and hemicerebellectomized adult cats (21 days postoperative). In the deafferented RN (contralateral to the lesion) as well as in the adjacent dorsolateral reticular formation, a marked increase in the number of GAD-positive perikarya was observed. In this mesencephalic area, some neurons may therefore increase their endogenous levels of immunodetectable GAD, as a response to cerebellar deafferentation. This can be viewed as one of the events contributing to functional recovery.

摘要

通过谷氨酸脱羧酶（GAD）免疫组织化学鉴定，对完整和半侧小脑切除的成年猫（术后21天）红核（RN）中的γ-氨基丁酸能神经元进行了比较图谱分析。在去传入的红核（与损伤对侧）以及相邻的背外侧网状结构中，观察到GAD阳性核周体数量显著增加。因此，在这个中脑区域，一些神经元可能会增加其免疫可检测GAD的内源性水平，作为对小脑去传入的反应。这可以被视为有助于功能恢复的事件之一。