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To block or not to block: Targeting SK channels in diseased hearts.

作者信息

Terentyev Dmitry, Belevych Andriy E, Choi Bum-Rak, Hamilton Shanna

机构信息

Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Wexner Medical Center, The Ohio State University, Columbus, OH, United States of America.

Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Wexner Medical Center, The Ohio State University, Columbus, OH, United States of America.

出版信息

J Mol Cell Cardiol. 2023 Oct;183:98-99. doi: 10.1016/j.yjmcc.2023.09.005. Epub 2023 Sep 23.

Abstract
摘要

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Enhanced Ca-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation.
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First Clinical Study with AP30663 - a K 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation.
Clin Transl Sci. 2020 Nov;13(6):1336-1344. doi: 10.1111/cts.12835. Epub 2020 Jul 29.
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Impact of I Voltage and Ca/Mg-Dependent Rectification on Cardiac Repolarization.
Biophys J. 2020 Aug 4;119(3):690-704. doi: 10.1016/j.bpj.2020.06.022. Epub 2020 Jun 27.
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Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.
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