Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto 612-8555, Japan; Department of Clinical and Translational Science, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto 612-8555, Japan; Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.
Diabetes Res Clin Pract. 2023 Nov;205:110919. doi: 10.1016/j.diabres.2023.110919. Epub 2023 Sep 22.
This cohort study intended to elucidate the association between serum uric acid (SUA) levels and cardiovascular disease events in Japanese patients with obesity.
Altogether, 450 obese Japanese outpatients were enrolled in a multicenter prospective cohort Japan, the Japan Obesity and Metabolic Syndrome Study. Primary analysis regarding the measurements of cardiovascular risk factors, including SUA levels, and the occurrence of macrovascular complications was based on following the participants over a 5-year period.
Of the eligible patients, 335 (74.4%) were followed into the fifth year. During the study period, 15 coronary heart disease, 7 stroke, and 6 arteriosclerosis obliterans events occurred in 39 patients. The CVD incidence rate was 15.8 per 1000 person-years. In the analysis of adjusted models for traditional risk factors, hyperuricemia was a significant factor for the incidence of CVD events, especially in female obese patients. Additionally, we estimated the association between SUA levels and CVD events using cubic spline models, which showed a U-shaped association in both male and female patients.
SUA is an effective predictor of CVD events in female obese patients and a risk factor for CVD incident in obese patients.
本队列研究旨在阐明血清尿酸（SUA）水平与日本肥胖患者心血管疾病事件之间的关联。
共有 450 名日本肥胖门诊患者参与了这项多中心前瞻性队列研究——日本肥胖与代谢综合征研究。主要分析是基于对心血管风险因素（包括 SUA 水平）的测量和 5 年内大血管并发症的发生情况，对参与者进行随访。
在符合条件的患者中，335 名（74.4%）患者随访至第 5 年。研究期间，39 名患者中发生了 15 例冠心病、7 例中风和 6 例动脉硬化闭塞症。CVD 的发病率为每 1000 人年 15.8 例。在对传统危险因素进行调整模型的分析中，高尿酸血症是 CVD 事件发生的一个显著因素，尤其是在女性肥胖患者中。此外，我们使用三次样条模型估计了 SUA 水平与 CVD 事件之间的关联，结果显示在男性和女性患者中均呈 U 形关联。
SUA 是女性肥胖患者心血管疾病事件的有效预测指标，也是肥胖患者心血管疾病发病的危险因素。
