Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, MP 474005, India.
Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Harisingh Gour Central University, Sagar, MP 470003, India.
Drug Discov Today. 2023 Nov;28(11):103786. doi: 10.1016/j.drudis.2023.103786. Epub 2023 Sep 22.
Various polymeric materials have been investigated to produce unique modes of delivery for drug modules to achieve either temporal or spatial control of bioactives delivery. However, after intravenous administration, phagocytic cells quickly remove these nanostructures from the systemic circulation via the reticuloendothelial system (RES). To overcome these concerns, ecofriendly block copolymers are increasingly being investigated as innovative carriers for the delivery of bioactives. In this review, we discuss the design, fabrication techniques, and recent advances in the development of block copolymers and their applications as drug carrier systems to improve the physicochemical and pharmacological attributes of bioactives.
各种聚合材料已经被研究用于产生独特的药物模块传递模式，以实现生物活性物质传递的时间或空间控制。然而，静脉给药后，吞噬细胞通过网状内皮系统（RES）迅速将这些纳米结构从全身循环中清除。为了解决这些问题，越来越多的环保嵌段共聚物被研究作为生物活性物质传递的创新载体。在这篇综述中，我们讨论了嵌段共聚物的设计、制备技术和最新进展，以及它们作为药物载体系统的应用，以改善生物活性物质的物理化学和药理学性质。
