ET 陷阱：子痫前期的潜在治疗方法。
ET-traps: Potential therapeutics for preeclampsia.
机构信息
ET-traps, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, UK; Accelerate Cambridge, Judge Business School, University of Cambridge, UK; Imperial College London, UK.
ET-traps, Cambridge, UK; Indian Institute of Management, Ahmedabad, India; National University of Singapore, Singapore.
出版信息
Drug Discov Today. 2023 Nov;28(11):103787. doi: 10.1016/j.drudis.2023.103787. Epub 2023 Sep 22.
Elevated endothelin-1 (ET-1) has been implicated in several diseases including preeclampsia, where it causes the induction of hypertension, oxidative stress, endoplasmic reticulum stress, microvascular dysfunction and tissue damage in different organs. ET-traps are Fc-fusion proteins with a design based on the physiological receptors of ET-1. This paper discusses the potential use of ET-traps as a therapeutic for preeclampsia. ET-traps potently bind and sequester pathologically elevated ET-1 to significantly reduce different markers of pathology to non-disease levels with no toxicity.
内皮素-1（ET-1）水平升高与多种疾病相关，包括子痫前期，它可导致高血压、氧化应激、内质网应激、微血管功能障碍和不同器官的组织损伤。ET 陷阱是基于 ET-1 生理受体设计的 Fc 融合蛋白。本文讨论了 ET 陷阱作为子痫前期治疗药物的潜在用途。ET 陷阱能强力结合和隔离病理性升高的 ET-1，可显著降低不同病理标志物至非疾病水平，且无毒性。
Zotero 插件