[Acceptance of pre-exposure prophylaxis and post-exposure prophylaxis against HIV and related factors in men who have sex with men in Shandong Province].

To understand the use of pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) and related factors in men who have sex with men (MSM) in Shandong Province, and provide reference for the promotion of PrEP and PEP in MSM. From April to July in 2022, MSM were recruited from 7 sentinel surveillance sites in Shandong Province for a questionnaire survey, and the sample size of each city site was 400. The information about sociodemographic characteristics, sexual behaviors, the uses of PrEP and PEP and others were collected from the MSM, and blood samples were collected from them for HIV and syphilis testing. A total of 2 815 MSM were investigated, the majority of them were aged less than 30 years (55.7%, 1 569/2 815), unmarried (68.6%, 1 931/2 815) and had education background of college and above (56.5%, 1 590/2 815). Only 9.2% (258/2 815) had used PrEP and 10.8% (305/2 815) had used PEP. Multivariate logistic regression showed that factors associated with high likelihood of PrEP use in MSM included age ≤30 years (a=4.04, 95%:1.25-13.01), self-perceived lower risk of HIV infection (a=1.76, 95%:1.16-2.68), group sex and commercial sex in the past six months (a=1.51, 95%: 1.10-2.09; a=1.69, 95%: 1.16-2.47), new-type drug use (a=1.53, 95%: 1.11-2.11), receiving peer education (a=1.56, 95%: 1.03-2.37), other people using PrEP (a=3.29, 95%: 2.48-4.36), and being HIV negative (a=8.40, 95%:1.12-63.12). Factor associated with low likelihood of PrEP use in MSM was anal sex with casual partner (a=0.67, 95%:0.49-0.90). Factors associated with high likelihood of PEP use in MSM included age under 50 years (≤30 years old: a=2.41, 95%:1.02-5.69; 31-49 years old: a=3.33, 95%1.42-7.85), no self-perceived risk for HIV infection (a=1.87, 95%:1.12-3.11), group sex in the past six months (a=1.68, 95%:1.23-2.29), new-type drug use (a=3.86, 95%:2.94-5.07) and receiving no peer education (a=1.54, 95%:1.12-2.12). In Shandong, a higher proportion of MSM used PrEP and PEP. Peer education and self-perceived HIV infection risk education should be strengthened to increase the rates of PrEP and PEP use in MSM.