Scientific Research and Strategy, Aetion, Inc., New York, New York, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Pharmacoepidemiol Drug Saf. 2024 Jan;33(1):e5697. doi: 10.1002/pds.5697. Epub 2023 Sep 25.
Describe patient characteristics and pregnancy outcomes among all pregnant patients, and additionally describe infant outcomes among the subset with linked infants in the Maternal Outcomes Masterset (MOM).
We used closed claims within the MOM data to identify publicly and privately insured patients at the first record of pregnancy January 1, 2018-December 1, 2021, with ≥180 days baseline enrollment. We described characteristics during baseline and follow-up (until an observed pregnancy endpoint, disenrollment, or 42-week maximum). We described maternal and infant characteristics overall and by infant linkage and contextualized them within national statistics.
Among the 1 438 861 pregnant patients meeting the study criteria, the most common pregnancy endpoint recorded was live birth (42%) followed by spontaneous abortion (14%). Among 602 721 patients with a live birth, 99% had a week-specific gestational age recorded and 35% had at least one linked infant. Patients with infant linkage and sufficient follow-up (N = 155 621) had similar baseline comorbidities, pregnancy complications, and gestational age at delivery as those without any linkage. However, more patients with linkage had commercial coverage (70% vs. 31%), and were therefore older (50% vs. 31% aged ≥30 years) and more likely to have an unknown race (57% vs. 34%).
In this large sample of pregnant patients, maternal and infant characteristics generally align with national statistics, providing confidence in the use of this data source for pregnancy research. Further, confirmation that the subset of patients with infant linkage is similar to the overall pregnancy cohort provides assurance that this subset can be considered representative.
描述所有孕妇的患者特征和妊娠结局，并在母婴结局主数据集（MOM）中对具有关联婴儿的亚组描述婴儿结局。
我们使用 MOM 数据中的封闭索赔来识别 2018 年 1 月 1 日至 2021 年 12 月 1 日首次记录妊娠的公共和私人保险患者，且基线登记时间≥180 天。我们描述了基线和随访期间（直到观察到妊娠终点、退保或最长 42 周）的特征。我们总体描述了母婴特征，并按婴儿关联进行了描述，并将其置于国家统计数据的背景下。
在符合研究标准的 1438861 名孕妇中，记录的最常见妊娠结局是活产（42%），其次是自然流产（14%）。在 602721 名活产患者中，99%记录了特定周的胎龄，35%至少有一个关联婴儿。有婴儿关联且有足够随访的患者（N=155621）与无任何关联的患者在基线合并症、妊娠并发症和分娩时的胎龄方面相似。然而，更多有联系的患者具有商业保险（70%对 31%），因此年龄更大（50%对 31%年龄≥30 岁），并且更有可能是未知种族（57%对 34%）。
在这个大型孕妇样本中，母婴特征通常与国家统计数据一致，为使用该数据源进行妊娠研究提供了信心。此外，确认具有婴儿关联的亚组与总体妊娠队列相似，确保了该亚组可以被认为是有代表性的。
