Perelman R H, Engle M J, Palta M, Kemnitz J W, Farrell P M
Pediatr Res. 1986 Oct;20(10):987-91. doi: 10.1203/00006450-198610000-00019.
Indices of lung maturation were assessed in 58 rhesus fetuses at five gestational ages during the last trimester of nonhuman primate pregnancy to determine whether fetal sex influences lung maturation. In addition to analysis of whole lung phospholipids, glycogen, protein, DNA, and pressure-volume curves surfactant fraction phosphatidylcholine (PC) was quantitated following isolation by sucrose gradient centrifugation and a combination of predictors were assessed by all possible subsets regression to attain a composite "maturity index." For the total population, there was a uniform progression in physical growth characteristics, lung destensibility and stability and phospholipids with advancing gestation. The quantitative change in surfactant fraction PC concentration for both sexes was considerably greater than that observed for whole lung PC between 135 days gestation and term. Further, the increase in surfactant PC occurred in association with improving lung destensibility and deflation stability prior to maximum changes in the whole lung PC or disaturated PC concentration. There were no statistically discernible differences in biochemical or physiological assessment between sexes at any gestational age. These data in nonhuman primates suggest that documented differences in survival from the respiratory distress syndrome between males and females do not result from a discordance in lung maturation as a function of time throughout the last trimester of gestation.
在非人类灵长类动物妊娠晚期的五个孕龄阶段，对58只恒河猴胎儿的肺成熟指标进行了评估，以确定胎儿性别是否会影响肺成熟。除了分析全肺中的磷脂、糖原、蛋白质、DNA以及压力-容积曲线外，还通过蔗糖梯度离心法分离出表面活性物质组分磷脂酰胆碱（PC）并进行定量分析，同时通过所有可能的子集回归评估一组预测指标，以得出一个综合的“成熟指数”。对于总体而言，随着妊娠进展，身体生长特征、肺扩张性和稳定性以及磷脂均呈现出一致的进展。在妊娠135天至足月期间，两性表面活性物质组分PC浓度的定量变化远大于全肺PC的变化。此外，表面活性物质PC的增加与肺扩张性和放气稳定性的改善相关，且早于全肺PC或双饱和PC浓度的最大变化。在任何孕龄阶段，两性之间在生化或生理评估方面均无统计学上可辨别的差异。这些非人类灵长类动物的数据表明，文献记载的男性和女性呼吸窘迫综合征存活率的差异并非源于妊娠晚期整个阶段肺成熟随时间的不一致。
