Lejeune C, Maudieu P, Robin M, Nectoux M
Pediatrie. 1986 Mar;41(2):95-104.
The authors have studied the incidence and short term prognosis of neonatal bacterial infections among 3,833 newborn babies admitted into 12 intensive care and/or neonatal units of Ile-de-France (Paris region) during 1984. this study was carried out with a computerized data base system. Septicemia was present in 3% of the total population, purulent meningitis in 0/6% and urinary tract infection in 1.4%. The authors have found a great incidence of group B streptococci (26% of septicemia) and e. coli (18% of septicemia). The frequency of use of antibiotics is very different among the units, without evidence of correlation with therapeutic results or with incidence of demonstrated bacterial infections. So, it appears necessary to reevaluate the indications of antibiotherapy, with more objective arguments. The authors emphasize the interest for such studies of computerized epidemiologic multicentric works.
作者对1984年入住法国法兰西岛（巴黎地区）12个重症监护和/或新生儿病房的3833名新生儿的新生儿细菌感染发病率及短期预后进行了研究。本研究使用计算机数据库系统开展。败血症在总人群中的发生率为3%，化脓性脑膜炎为0.6%，尿路感染为1.4%。作者发现B组链球菌感染率很高（占败血症的26%），大肠杆菌感染率为（占败血症的18%）。各病房抗生素的使用频率差异很大，且没有证据表明与治疗效果或已证实的细菌感染发生率相关。因此，似乎有必要用更客观的依据重新评估抗菌治疗的指征。作者强调了此类计算机化流行病学多中心研究的意义。
