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库尼斯综合征与应激性心肌病:由肾上腺素相连的两种综合征——“ATAK”综合征

Kounis and Takotsubo, Two Syndromes Bound by Adrenaline: The "ATAK" Complex.

作者信息

Ballesteros Ravi Vazirani, Polo Juan Carlos Gómez, Olmos Carmen, Vilacosta Isidre

机构信息

Department of Cardiology, Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain.

出版信息

Case Rep Cardiol. 2023 Sep 14;2023:7706104. doi: 10.1155/2023/7706104. eCollection 2023.

DOI:10.1155/2023/7706104
PMID:37744893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10513855/
Abstract

. The term "ATAK" complex has been coined by the association of adrenaline, takotsubo, anaphylaxis and Kounis syndrome. We present an uncommon case of an "ATAK" complex with biphasic onset and a midventricular takotsubo pattern. . A 50-year-old male was brought to the emergency department in anaphylactic shock. He had progressive exertional dyspnea and angina for the past 2 days. The intravenous administration of adrenaline for anaphylactic shock resulted in chest pain and concerning ECG repolarization findings. The patient was immediately transferred to the catheterization laboratory. Coronary angiography showed a midventricular ballooning pattern without significant coronary stenosis, with subsequent recovery during hospitalization, suggestive of takotsubo syndrome. The allergy tests remained inconclusive for the trigger. . Adrenaline-mediated stress is the link between these two entities, in which Kounis syndrome itself or anaphylactic shock treatment (adrenaline) are potential triggers for takotsubo syndrome.

摘要

“ATAK”综合征这一术语是由肾上腺素、应激性心肌病、过敏反应和库尼斯综合征联合而成。我们报告一例罕见的具有双相发作和心室中部应激性心肌病模式的“ATAK”综合征病例。一名50岁男性因过敏性休克被送往急诊科。在过去两天里,他有进行性劳力性呼吸困难和心绞痛。因过敏性休克静脉注射肾上腺素后出现胸痛及令人担忧的心电图复极异常表现。患者立即被转至导管室。冠状动脉造影显示心室中部气球样改变,无明显冠状动脉狭窄,住院期间随后恢复,提示应激性心肌病综合征。过敏试验未能明确触发因素。肾上腺素介导的应激是这两种情况之间的联系,其中库尼斯综合征本身或过敏性休克治疗(肾上腺素)是应激性心肌病综合征的潜在触发因素。

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本文引用的文献

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Medicina (Kaunas). 2022 Jun 26;58(7):855. doi: 10.3390/medicina58070855.
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European Resuscitation Council Guidelines 2021: Adult advanced life support.欧洲复苏理事会指南 2021:成人高级生命支持。
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Takotsubo cardiomyopathy associated with Kounis syndrome: A clinical case of the "ATAK complex".与库尼综合征相关的应激性心肌病:“ATAK 综合征”的临床病例
J Cardiol Cases. 2019 May 1;20(2):52-56. doi: 10.1016/j.jccase.2019.03.007. eCollection 2019 Aug.
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Type 2 Kounis syndrome in an allergic woman: An uncommon presentation of acute coronary syndrome.一名过敏女性的2型库尼斯综合征:急性冠状动脉综合征的罕见表现。
J Cardiol Cases. 2013 Oct 29;8(6):176-178. doi: 10.1016/j.jccase.2013.08.003. eCollection 2013 Dec.
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Kounis syndrome: A review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome.库尼斯综合征:关于过敏性急性冠状动脉综合征的流行病学、诊断结果、管理及并发症的综述文章
Int J Cardiol. 2017 Apr 1;232:1-4. doi: 10.1016/j.ijcard.2017.01.124. Epub 2017 Jan 27.
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The ATAK complex (Adrenaline, Takotsubo, Anaphylaxis, and Kounis hypersensitivity -associated coronary syndrome) in neurological conditions.神经系统疾病中的ATAK综合征(肾上腺素、应激性心肌病、过敏反应和库尼斯超敏反应相关冠状动脉综合征)
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Kounis syndrome: A concise review with focus on management.Kounis 综合征:重点关注治疗的简明综述。
Eur J Intern Med. 2016 May;30:7-10. doi: 10.1016/j.ejim.2015.12.004. Epub 2016 Jan 12.
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