Yin Feiyan, Shi Zhidao, Ma Xiquan, Ding Kai, Zhang Yuan, Ma Sha
Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China.
Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Front Microbiol. 2023 Sep 6;14:1253156. doi: 10.3389/fmicb.2023.1253156. eCollection 2023.
Clozapine is considered one of the most effective antipsychotic drugs, but it is most likely to cause metabolic abnormalities. Researchers have studied the causes of metabolic abnormalities caused by clozapine from multiple perspectives, but the reasons remain unclear.
Characterize the gut microbiota of people with schizophrenia taking clozapine, exploring the association between gut microbiota and glucose lipid metabolic markers in schizophrenia patients taking clozapine.
Sixty-one long-term inpatients with schizophrenia in clozapine monotherapy were selected as study subjects. We got four subgroups by sex and the presence of metabolic syndrome.
16s analysis technology was applied at the genus level to determine the classification of gut microbiota. Then we compared the characteristics of gut microbiota and the association of gut microbiota with glucose lipid metabolic markers in each group.
We found differences in the diversity of gut microbiota among groups. The association between gut microbiota and glucose lipid metabolic markers was complicated. Gender was an important differentiating factor. has a low abundance. However, it was the only genus associated with glycemic or lipids in each group. Among metabolic syndromes, was positively correlated with most lipids in females but negatively correlated in males, showing gender differences. In female non-metabolic syndromes, lost its probiotic character; instead, showing pathogenicity, which has strong positive correlations with fasting blood glucose and low-density lipoprotein but negative correlations with Apolipoprotein A1. Maybe schizophrenia, taking clozapine, and gender factors influenced the gut microbiota, which complicated our findings. The significance of the results remains to be determined by in-depth studies.
氯氮平被认为是最有效的抗精神病药物之一，但它最有可能导致代谢异常。研究人员已从多个角度研究了氯氮平引起代谢异常的原因，但原因仍不清楚。
对服用氯氮平的精神分裂症患者的肠道微生物群进行特征分析，探索服用氯氮平的精神分裂症患者肠道微生物群与糖脂代谢标志物之间的关联。
选取61例长期接受氯氮平单药治疗的精神分裂症住院患者作为研究对象。根据性别和是否存在代谢综合征将其分为四个亚组。
在属水平上应用16s分析技术来确定肠道微生物群的分类。然后我们比较了各组肠道微生物群的特征以及肠道微生物群与糖脂代谢标志物的关联。
我们发现各组肠道微生物群的多样性存在差异。肠道微生物群与糖脂代谢标志物之间的关联很复杂。性别是一个重要的区分因素。[此处原文缺失具体菌属名称]丰度较低。然而，它是每组中唯一与血糖或血脂相关的菌属。在代谢综合征患者中，[此处原文缺失具体菌属名称]在女性中与大多数血脂呈正相关，而在男性中呈负相关，表现出性别差异。在女性非代谢综合征患者中，[此处原文缺失具体菌属名称]失去了益生菌特性；相反，表现出致病性，与空腹血糖和低密度脂蛋白呈强正相关，但与载脂蛋白A1呈负相关。也许精神分裂症、服用氯氮平和性别因素影响了肠道微生物群，这使得我们的研究结果变得复杂。结果的意义仍有待深入研究来确定。
