[刚果2257名新生儿血红蛋白病的流行病学研究]
[Epidemiologic study of hemoglobinopathies in the Congo in 2,257 newborn infants].
作者信息
Djembo-Taty M, Tchiloemba M, Galacteros F, Rosa J, Lissouba P
出版信息
Nouv Rev Fr Hematol (1978). 1986;28(4):249-51.
PMID:3774535
Abstract
A systematic examination of 2,257 Congolese newborns from Brazzaville for abnormal hemoglobins has been conducted. Gene frequency for HbS was 0.117; no HbC was found. Of the sample 14.4% had detectable amounts of Hb Bart's. Beta-thalassemia trait frequency was approximately estimated to 0.3%, 5 mutations of gamma chain, and 1 mutation for alpha chain were detected.
摘要
对来自布拉柴维尔的2257名刚果新生儿进行了异常血红蛋白的系统检查。血红蛋白S（HbS）的基因频率为0.117；未发现血红蛋白C（HbC）。在样本中，14.4%的人可检测到血红蛋白Bart's。β地中海贫血特征频率约估计为0.3%，检测到5种γ链突变和1种α链突变。
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