Zhang Bai-Wen, Dong Hao, Wu Zhe, Jiang Xi, Zou Wei
Heilongjiang University of Chinese Medicine, Harbin, 150040, People's Republic of China.
Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
J Inflamm Res. 2023 Sep 18;16:4087-4101. doi: 10.2147/JIR.S425966. eCollection 2023.
Neuralgia is a frequently occurring condition that causes chronic pain and burdens both patients and their families. Earlier research indicated that anti-inflammatory treatment, which was primarily utilized to address conditions like neuralgia, resulted in positive outcomes. However, recent years have witnessed the emergence of various novel mechanisms associated with pain-related disorders. This review provides a concise overview of the inflammatory mechanisms involved in neuralgia. It also examines recent advancements in research, exploring the influence of ion channels and synaptic proteins on neuralgia and its complications. Additionally, the interactions between these mechanisms are discussed with the aim of suggesting innovative therapeutic approaches and research directions for the management of neuralgia.
神经痛是一种常见疾病，会导致慢性疼痛，给患者及其家庭带来负担。早期研究表明，主要用于治疗神经痛等病症的抗炎治疗产生了积极效果。然而，近年来出现了各种与疼痛相关疾病相关的新机制。本综述简要概述了神经痛所涉及的炎症机制。它还研究了近期的研究进展，探讨离子通道和突触蛋白对神经痛及其并发症的影响。此外，还讨论了这些机制之间的相互作用，旨在为神经痛的管理提出创新的治疗方法和研究方向。
