Kawada A, Satoh Y, Fujiwara Y
Photodermatol. 1986 Aug;3(4):233-8.
A 5-year-old female Japanese patient with mild symptoms of xeroderma pigmentosum (XP), XP7OTO, was assigned to complementation group E following cell hybridization. XP7OTO showed lowered minimal erythema doses compared with those of normal Japanese and XP group A subjects at 290 and 300 nm of monochromatic ultraviolet (UV) light. The delayed peak reaction of UV erythema was characteristically observed in this particular group E patient. 254 nm UV-induced unscheduled DNA synthesis of XP7OTO skin fibroblasts was reduced to a level of 55% of normal. XP7OTO cells exhibited a twice higher sensitivity to 254 nm UV killing (n (extrapolation number) = 1.2, Do (mean lethal dose) = 2.2 J/m2) than did normal cells (n = 1.5, Do = 5.0 J/m2). The patient has, as yet, developed neither skin malignancies nor neurological abnormalities.
一名患有轻度着色性干皮病（XP）的5岁日本女性患者XP7OTO，在细胞杂交后被归为互补组E。与正常日本人和XP A组受试者相比，XP7OTO在290和300nm单色紫外线（UV）照射下的最小红斑剂量降低。在这个特定的E组患者中，紫外线红斑的延迟峰值反应具有特征性。254nm紫外线诱导的XP7OTO皮肤成纤维细胞的非预定DNA合成降低至正常水平的55%。XP7OTO细胞对254nm紫外线杀伤的敏感性（n（外推数）=1.2，Do（平均致死剂量）=2.2J/m2）是正常细胞（n=1.5，Do=5.0J/m2）的两倍。该患者尚未发生皮肤恶性肿瘤或神经异常。
