Kouhen Fadila, Oqbani Kenza, El Gouach Hanae, Ahnach Meriem, Dahbi Zineb
Laboratory of Neurosciences and Oncogenetics, Department of Radiotherapy, Mohammed VI Center for Research and Innovation, International University Hospital Sheikh Khalifa, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, MAR.
Department of Pathology, International University Hospital Sheikh Khalifa, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, MAR.
Cureus. 2023 Aug 23;15(8):e43959. doi: 10.7759/cureus.43959. eCollection 2023 Aug.
The management of refractory cutaneous T-cell lymphoma (CTCL) is challenging and requires a multimodal approach. Radiotherapy is one of the treatment options used in managing CTCL, particularly for localized disease or as a palliative measure to control symptoms in advanced cases. The rarity of the disease makes it difficult to conduct extensive clinical trials and gather sufficient data on the most effective treatment approaches. Lymphocytes are among the most sensitive cells to radiation's damaging effects. Because of this sensitivity, radiation therapy can be an effective treatment. This case illustrates the efficacy of radiotherapy and its potential as an effective treatment alternative for a severe and resistant CTCL to systemic therapy in a 61-year-old Moroccan patient. The patient underwent curative high-dose radiation therapy, utilizing three-dimensional conformal radiation therapy. At the 19-month follow-up post-radiotherapy, no evidence of local recurrence, either clinically or radiologically, was observed, and the patient maintained a good quality of life with unrestricted mobility of his arm.
难治性皮肤T细胞淋巴瘤（CTCL）的管理具有挑战性，需要采用多模式方法。放射治疗是用于管理CTCL的治疗选择之一，特别是对于局限性疾病或作为晚期病例控制症状的姑息措施。该疾病的罕见性使得难以进行广泛的临床试验并收集关于最有效治疗方法的足够数据。淋巴细胞是对辐射损伤作用最敏感的细胞之一。由于这种敏感性，放射治疗可以是一种有效的治疗方法。本病例说明了放射治疗的疗效及其作为一名61岁摩洛哥患者严重且耐药的CTCL全身治疗有效替代方案的潜力。该患者接受了根治性高剂量放射治疗，采用三维适形放射治疗。放疗后19个月的随访中，未观察到临床或放射学上局部复发的证据，患者保持了良好的生活质量，手臂活动不受限制。
