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结节病的首发表现为纵向广泛横贯性脊髓炎

Longitudinally Extensive Transverse Myelitis as a First Manifestation of Sarcoidosis.

作者信息

Rodrigues Ricardo A, Alves Telma, Sousa João A, Jorge Andre, Geraldo Argemiro

机构信息

Internal Medicine, University Hospital Center of Coimbra, Coimbra, PRT.

Neurology, University Hospital Center of Coimbra, Coimbra, PRT.

出版信息

Cureus. 2023 Aug 24;15(8):e44037. doi: 10.7759/cureus.44037. eCollection 2023 Aug.

Abstract

Longitudinally extensive transverse myelitis (LETM) is a debilitating inflammatory spinal cord lesion involving several spinal segments. There are several possible etiologies, with spinal cord sarcoidosis being a rare cause of LETM. Spinal cord sarcoidosis is, in itself, a rare manifestation of sarcoidosis that can be difficult to diagnose, especially in patients with no prior history of systemic sarcoidosis, frequently leading to a delayed diagnosis. We report the case of a 53-year-old man who developed LETM as the first manifestation of sarcoidosis. The patient presented with progressive lower limb weakness, urinary retention, sensory disturbances, and muscle spasms. Imaging studies showed hyperintense lesions extending over multiple spinal segments. After the exclusion of other causes and a lymph node biopsy showing non-caseating granulomas, the diagnosis of LETM secondary to sarcoidosis was confirmed.

摘要

长节段横贯性脊髓炎(LETM)是一种累及多个脊髓节段的使人衰弱的炎症性脊髓病变。病因有多种,脊髓结节病是LETM的罕见病因。脊髓结节病本身就是结节病的一种罕见表现,可能难以诊断,尤其是在没有系统性结节病既往史的患者中,常常导致诊断延迟。我们报告一例53岁男性患者,其以LETM作为结节病的首发表现。该患者出现进行性下肢无力、尿潴留、感觉障碍和肌肉痉挛。影像学检查显示多个脊髓节段有高强度病变。在排除其他病因且淋巴结活检显示非干酪样肉芽肿后,确诊为结节病继发的LETM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e66/10517641/89c86734b222/cureus-0015-00000044037-i01.jpg

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