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癫痫的卡马西平治疗加重病态窦房结综合征。

Sick sinus syndrome aggravated by carbamazepine therapy for epilepsy.

作者信息

Hewetson K A, Ritch A E, Watson R D

出版信息

Postgrad Med J. 1986 Jun;62(728):497-8. doi: 10.1136/pgmj.62.728.497.

DOI:10.1136/pgmj.62.728.497
PMID:3774685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2418799/
Abstract

A case of sick sinus syndrome aggravated by carbamazepine prescribed for epilepsy is described. A 70 year old woman with previously stable psychomotor epilepsy experienced syncope of increased frequency after her anticonvulsant was changed to carbamazepine. ECG monitoring confirmed a severe sick sinus syndrome which improved on carbamazepine withdrawal. Failure to distinguish carbamazepine-induced cardiac syncope from epileptic attacks may lead to an increase in dosage and aggravation of syncope.

摘要

本文描述了一例因用于治疗癫痫的卡马西平而加重的病态窦房结综合征病例。一名70岁女性，既往精神运动性癫痫病情稳定，在抗惊厥药物换成卡马西平后，晕厥发作频率增加。心电图监测证实为严重的病态窦房结综合征，停用卡马西平后病情改善。未能区分卡马西平引起的心脏性晕厥和癫痫发作可能导致剂量增加和晕厥加重。

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Sick sinus syndrome aggravated by carbamazepine therapy for epilepsy.癫痫的卡马西平治疗加重病态窦房结综合征。
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Carbamazepine-induced sinus node dysfunction.卡马西平诱发的窦房结功能障碍。
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Pause for thought? Syncope and sinus arrest as the presenting feature of temporal lobe epilepsy.停下来思考一下？晕厥和窦性停搏作为颞叶癫痫的首发症状。
Acute Med. 2014;13(2):65-7.
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Syncope and sudden death attributed to carbamazepine.卡马西平所致的晕厥与猝死
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Lithium- and carbamazepine-associated sinus node dysfunction: nine-year experience in a psychiatric hospital.锂盐和卡马西平相关的窦房结功能障碍：一家精神病医院的九年经验
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A rare cause of 2:1 atrioventricular block: carbamazepine.2:1房室传导阻滞的罕见病因：卡马西平。
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Manic state with carbamazepine therapy of seizures.卡马西平治疗癫痫时出现躁狂状态。
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引用本文的文献

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Carbamazepine induced atrial tachycardia with complete AV block.卡马西平诱发伴有完全性房室传导阻滞的房性心动过速。
Hippokratia. 2014 Apr;18(2):185-6.

本文引用的文献

1
Cardiac conduction disturbances during carbamazepine therapy.卡马西平治疗期间的心脏传导障碍。
Acta Neurol Scand. 1983 Jul;68(1):49-52. doi: 10.1111/j.1600-0404.1983.tb04814.x.
2
The antiarrhythmic actions of carbamazepine (Tegretol).
J Pharmacol Exp Ther. 1970 Jun;173(2):323-35.
3
Advanced heart block aggravated by carbamazepine.卡马西平加重的高度房室传导阻滞。
Br Heart J. 1975 Jun;37(6):668-71. doi: 10.1136/hrt.37.6.668.
4
Carbamazepine therapy complicated by nodal bradycardia and water intoxication.卡马西平治疗并发结性心动过缓和水中毒。
Aust N Z J Med. 1979 Jun;9(3):295-6. doi: 10.1111/j.1445-5994.1979.tb04142.x.
5
Carbamazepine and bradycardia.卡马西平与心动过缓
Lancet. 1978 May 20;1(8073):1097-8. doi: 10.1016/s0140-6736(78)90940-6.