GBS 透明质酸酶通过 TLR2/4 和 IL-10 依赖途径在妊娠相关感染中发挥免疫抑制作用。
GBS hyaluronidase mediates immune suppression in a TLR2/4- and IL-10-dependent manner during pregnancy-associated infection.
机构信息
Center for Global Infectious Disease Research, Seattle Children's Research Institute , Seattle, Washington, USA.
Department of Global Health, University of Washington , Seattle, Washington, USA.
出版信息
mBio. 2023 Oct 31;14(5):e0204923. doi: 10.1128/mbio.02049-23. Epub 2023 Sep 25.
Bacteria such as GBS can cause infections during pregnancy leading to preterm births, stillbirths, and neonatal infections. The interaction between host and bacterial factors during infections in the placenta is not fully understood. GBS secretes a hyaluronidase enzyme that is thought to digest host hyaluronan into immunosuppressive disaccharides that dampen TLR2/4 signaling, leading to increased bacterial dissemination and adverse outcomes. In this study, we show that GBS HylB mediates immune suppression and promotes bacterial infection during pregnancy that requires TLR2, TLR4, and IL-10. Understanding the interaction between host and bacterial factors can inform future therapeutic strategies to mitigate GBS infections.
细菌（如 GBS）可在孕期引发感染，导致早产、死产和新生儿感染。在胎盘感染过程中，宿主和细菌因素之间的相互作用尚未完全阐明。GBS 分泌透明质酸酶，该酶被认为可将宿主透明质酸分解为免疫抑制二糖，从而抑制 TLR2/4 信号传导，导致细菌播散增加和不良后果。在这项研究中，我们表明 GBS 的 HylB 介导免疫抑制并促进孕期细菌感染，该过程需要 TLR2、TLR4 和 IL-10。了解宿主和细菌因素之间的相互作用可以为减轻 GBS 感染的未来治疗策略提供信息。
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